A Study to Assess Benign Joint Hypermobility Syndrome in Children With a History of Wheezing or Asthma

Status:	Completed
Conditions:	Asthma, Orthopedic, Pulmonary
Therapuetic Areas:	Pulmonary / Respiratory Diseases, Orthopedics / Podiatry
Healthy:	No
Age Range:	6 - 16
Updated:	4/21/2016
Start Date:	June 2014
End Date:	June 2015

The purpose of this study is to assess benign joint hypermobility syndrome (BJHS) in
children with a history of wheezing or asthma. BJHS is a common syndrome of joint and
connective tissue laxity without any other rheumatologic disease. This assessment will be
performed by using either method below depending upon if the child has a history of wheezing
or severe asthma:

1. Determine the correlation, if there is an increased rate of BJHS in children with a
history of wheezing as well as if there is an increased history of wheezing in children
with BJHS; or

2. Determine asthma control, lung function and asthma exacerbations (a flare up or acute
worsening of symptoms) in children with BJHS compared to children with asthma without
BJHS, to assess if it BJHS is associated more with children with severe asthma.

Inclusion Criteria:

- All children ages 6-16 with a history of wheezing or asthma

Exclusion Criteria:

- For subjects with a history of Wheezing: History of chronic lung disease or
prematurity, chronic aspiration, congenital anomalies of the upper and lower airway,
primary ciliary dyskinesia, cystic fibrosis, history of heart failure, immune
deficiency, or any inflammatory arthritis.

- For Subjects with a history of Asthma: current acute respiratory exacerbation,
history of chronic lung disease of prematurity, chronic aspiration, congenital
anomalies of the upper or lower airway, primary ciliary dyskinesia, cystic fibrosis,
restrictive lung disease, history of heart failure, immune deficiency, or
inflammatory arthritis.

We found this trial at

sites

University of Louisville Allergy and Immunology

Louisville, Kentucky 40202

from

Louisville, KY