Escalating Temporary Gastric Electrical Stimulation (GES) for Severe Gastroparesis

This study will look to determine the clinical benefit placing temporary gastric electrical
stimulation, the ability to predict the clinical response to surgical implantation of GES,
and the feasibility and patient tolerability of endoscopic placement of temporary Gastric
Electrical Stimulator (t-GES),

Inclusion Criteria:

- At least 3 months of gastroparesis-related symptoms, such as nausea, emesis, and/or
retching

- Solid phase 4-hr gastric scintigraphy is consistent with gastroparesis within 3 months
of study enrollment*

- retention at 2 hr: >60% or

- retention at 4 hr: >10% *Based on International consensus on gastric scintigraphy

Exclusion Criteria:

- Gastric outlet, small bowel, or colon obstruction.

- Small bowel malrotation

- Inflammatory bowel disease

- Contraindication for surgical implantation of GES

- Presence of illness that may require MRI during the study; such as pituitary tumor,
herniated disc, spinal stenosis, multiple sclerosis, etc.

- Significant comorbidity due to sever cardiovascular, renal, pulmonary, or liver
disease.

- Significant coagulopathy

- Non-ambulatory patients: bed-ridden, nursing home resident, etc.

- Pregnancy

- Unable to give own informed consent

- Prisoners