A Two-part, Single-dose, Randomized Study to Evaluate the Safety of Supra-therapeutic Doses of RO7033877 and to Investigate the Effect of RO7033877 on the QTc Interval

Inclusion Criteria:

- Healthy male or female of non-childbearing potential participants, 18 to 65 years of
age, inclusive

- Healthy status is defined as the absence of evidence of any clinically significant,
active, or chronic disease following a detailed medical and surgical history, a
complete physical examination and vital signs, 12-lead ECG, hematology, blood
chemistry, serology and urinalysis and confirmed by a creatinine clearance estimated
by formula of Cockcroft-Gault > 80 mL/min/1.73 m2

- Postmenopausal or surgically sterile females (bilateral oophorectomy or hysterectomy
performed at least 6 months prior to study participation)

- A body mass index (BMI) between 18 and 30 kg/m2 inclusive and minimum body weight >/=
50 kg, inclusive

- For men with a female partner(s) of childbearing potential: agreement to use a
barrier method of contraception during the treatment period and for at least 3 months
after the last dose of study drug

- Participants who are non-smokers, or former smokers who have not smoked for at least
45 days prior to screening (former smokers are to have a total of < 10 pack year
smoking history)

Exclusion Criteria:

- Women of childbearing potential

- Pregnant or lactating women

- Men with female partners who are lactating or are pregnant

- History of any clinically significant disease, e.g. gastrointestinal, renal, hepatic,
cardiovascular, endocrine, hematologic or allergic disease(s), metabolic disorder,
cancer (may have had basal or squamous cell carcinoma of skin or cervix as long as
surgically removed or deemed cured by cryotherapy, laser therapy, conization, etc.,
with stability for the past 2 years)

- Any major illness within one month before the first dose of study drug or any febrile
illness within one week prior to screening and up to first dose administration

- Any prescribed medications taken within 4 weeks prior to first dosing or within 5
times the elimination half-life of the medication prior to first dosing (whichever is
longer)

- Any preparations containing St. John's Wort taken within 4 weeks prior to first
dosing

- Any other over-the-counter medications, including vitamins or herbal remedies, taken
within 14 days prior to first dosing or within 5 times the elimination half-life of
the medication prior to first dosing (whichever is longer); acetaminophen is the only
exception

- Taking any nutrients known to modulate cytochrome P450 (CYP) 3A activity.
Participants will be instructed to abstain from consuming grapefruit, Seville
oranges, and grapefruit- or Seville orange-containing products within 2 weeks prior
to administration of study drugs

- Regular consumption of large amounts of caffeine or xanthine-containing substances
(e.g. >/= 5 cups of coffee/day, tea, cola, Mountain Dew, chocolate, diet pills,
"energy drinks" or any other type of stimulant) or unable to refrain from consumption
of caffeine or xanthine-containing substances from 72 hours prior to each entry in
the clinic and during the in-house periods

- Any medication that inhibits active tubular secretion (e.g. probenecid, H2 receptor
antagonists, trimethoprim) within 4 weeks prior to first dosing

- Participation in an investigational drug or device study within 60 days prior to
screening

- Concomitant disease or condition that could interfere with, or treatment of which
might interfere with, the conduct of the study, or that would, in the opinion of the
investigator, pose an unacceptable risk to the subject in this study

- History and/or family history of cardiac anomalies, e.g. congenital long QT syndrome,
unexplained syncope, or clinically significant abnormal ECG

- ECG evidence at screening or baseline of, e.g. atrial fibrillation, atrial flutter,
complete right or left bundle branch block and/or clinically relevant prolongation of
the PR interval as determined by the Investigator

Exclusion criteria for Part 2 only:

- History of allergy or sensitivity to moxifloxacin or other fluoroquinolones, and/or
history of tendon rupture when taking or considered time-wise related to consumption
of a fluoroquinolone