A Study to Evaluate Long-term Outcomes Following Treatment With ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 With or Without Ribavirin (RBV) in Adults With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection



Status:Active, not recruiting
Conditions:Infectious Disease, Hepatitis, Hepatitis, Hepatitis
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:18 - 99
Updated:10/26/2018
Start Date:June 12, 2014
End Date:May 5, 2020

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An Open-Label, Multicenter Study to Evaluate Long-term Outcomes With ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 With or Without Ribavirin (RBV) in Adults With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection (TOPAZ II)

The purpose of this study is to evaluate Long-term Outcomes following treatment with
ABT-450/r/ABT-267, ABT-333 with or without RBV in Adults With Genotype 1 Chronic Hepatitis C
Virus (HCV) Infection


Inclusion Criteria:

1. Females must be post-menopausal for more than 2 years or surgically sterile or
practicing specific forms of birth control

2. Chronic hepatitis C, genotype 1-infection (HCV RNA level greater than 1,000 IU/mL at
screening)

3. HCV genotype 1 infection per screening laboratory result

Exclusion Criteria:

1. Use of contraindicated medications within 2 weeks of dosing

2. Abnormal laboratory tests

3. Positive hepatitis B surface antigen and anti-Human Immunodeficiency Virus Antibody

4. Clinical history of liver decompensation

5. Presence of hepatocellular carcinoma at screening
We found this trial at
48
sites
4800 Belfort Road
Jacksonville, Florida 32256
1062
mi
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Jacksonville, FL
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Albuquerque, New Mexico 87131
522
mi
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Albuquerque, NM
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Atlanta, Georgia 30308
801
mi
from
Atlanta, GA
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402
mi
from
Aurora, CO
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?
mi
from
Austin, TX
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Bakersfield, California 93301
?
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Bakersfield, CA
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Baltimore, Maryland 21287
1149
mi
from
Baltimore, MD
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?
mi
from
Baytown, TX
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1442
mi
from
Boston, MA
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Bradenton, Florida 34209
?
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from
Bradenton, FL
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Catonsville, Maryland 21228
1142
mi
from
Catonsville, MD
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Charlotte, North Carolina 28204
958
mi
from
Charlotte, NC
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303 East Superior Street
Chicago, Illinois 60611
611
mi
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Chicago, IL
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Chicago, Illinois 60637
?
mi
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Chicago, IL
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Cincinnati, Ohio 45267
?
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Cincinnati, OH
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Detroit, Michigan 48202
?
mi
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Detroit, MI
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Egg Harbor Township, New Jersey 08234
?
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Egg Harbor Township, NJ
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1600 Southwest Archer Road
Gainesville, Florida 32610
1049
mi
from
Gainesville, FL
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1324 Wolf Park Drive
Germantown, Tennessee 38138
481
mi
from
Germantown, TN
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Houston, Texas 77004
572
mi
from
Houston, TX
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6410 Fannin Street
Houston, Texas 77030
572
mi
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Houston, TX
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Indianapolis, Indiana 46202
?
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Indianapolis, IN
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5901 West Olympic Boulevard
Los Angeles, California 90036
1174
mi
from
Los Angeles, CA
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1225 Fish Hatchery Road
Madison, Wisconsin 53715
574
mi
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Madison, WI
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Miami, Florida 33136
1320
mi
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Miami, FL
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?
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Murray, UT
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New Hyde Park, New York 11040
?
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New Hyde Park, NY
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1415 Tulane Avenue
New Orleans, Louisiana 70112
697
mi
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New Orleans, LA
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?
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New York, NY
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1290
mi
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New York, NY
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New York, New York 10032
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New York, NY
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Newark, New Jersey 07103
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Newark, NJ
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350 West Thomas Road
Phoenix, Arizona 85013
852
mi
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Phoenix, AZ
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Plymouth, Minnesota 55446
?
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Plymouth, MN
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Poughkeepsie, New York 12601
?
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Poughkeepsie, NY
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33 Staniford Street
Providence, Rhode Island 02905
1424
mi
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Providence, RI
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601 Elmwood Avenue
Rochester, New York 14642
1121
mi
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Rochester, NY
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?
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Saint Louis, MO
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?
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San Antonio, TX
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San Francisco, California 94115
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San Francisco, CA
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649 Harkle Road
Santa Fe, New Mexico 87505
472
mi
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Santa Fe, NM
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1100 9th Avenue
Seattle, Washington 98101
1410
mi
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Seattle, WA
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908 Jefferson Street
Seattle, Washington 98104
1409
mi
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Seattle, WA
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1800 East 70th Street
Shreveport, Louisiana 71105
433
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Shreveport, LA
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Statesville, North Carolina 28677
?
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Statesville, NC
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150
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Tulsa, OK
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Washington, District of Columbia 20010
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Washington,
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Wellington, Florida 33414
?
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Wellington, FL
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