A Study to Evaluate Long-term Outcomes Following Treatment With ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 With or Without Ribavirin (RBV) in Adults With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection



Status:Active, not recruiting
Conditions:Infectious Disease, Hepatitis, Hepatitis, Hepatitis
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:18 - 99
Updated:10/26/2018
Start Date:June 12, 2014
End Date:May 5, 2020

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An Open-Label, Multicenter Study to Evaluate Long-term Outcomes With ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 With or Without Ribavirin (RBV) in Adults With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection (TOPAZ II)

The purpose of this study is to evaluate Long-term Outcomes following treatment with
ABT-450/r/ABT-267, ABT-333 with or without RBV in Adults With Genotype 1 Chronic Hepatitis C
Virus (HCV) Infection


Inclusion Criteria:

1. Females must be post-menopausal for more than 2 years or surgically sterile or
practicing specific forms of birth control

2. Chronic hepatitis C, genotype 1-infection (HCV RNA level greater than 1,000 IU/mL at
screening)

3. HCV genotype 1 infection per screening laboratory result

Exclusion Criteria:

1. Use of contraindicated medications within 2 weeks of dosing

2. Abnormal laboratory tests

3. Positive hepatitis B surface antigen and anti-Human Immunodeficiency Virus Antibody

4. Clinical history of liver decompensation

5. Presence of hepatocellular carcinoma at screening
We found this trial at
48
sites
4800 Belfort Road
Jacksonville, Florida 32256
676
mi
from 43215
Jacksonville, FL
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Albuquerque, New Mexico 87131
1331
mi
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Albuquerque, NM
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Atlanta, Georgia 30308
434
mi
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Atlanta, GA
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1154
mi
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Aurora, CO
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?
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Austin, TX
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Bakersfield, California 93301
?
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Bakersfield, CA
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Baltimore, Maryland 21287
345
mi
from 43215
Baltimore, MD
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?
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Baytown, TX
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641
mi
from 43215
Boston, MA
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Bradenton, Florida 34209
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mi
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Bradenton, FL
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Catonsville, Maryland 21228
338
mi
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Catonsville, MD
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Charlotte, North Carolina 28204
349
mi
from 43215
Charlotte, NC
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303 East Superior Street
Chicago, Illinois 60611
274
mi
from 43215
Chicago, IL
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Chicago, Illinois 60637
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Chicago, IL
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Cincinnati, Ohio 45267
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Cincinnati, OH
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Detroit, Michigan 48202
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Detroit, MI
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Egg Harbor Township, New Jersey 08234
?
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Egg Harbor Township, NJ
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1600 Southwest Archer Road
Gainesville, Florida 32610
714
mi
from 43215
Gainesville, FL
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1324 Wolf Park Drive
Germantown, Tennessee 38138
500
mi
from 43215
Germantown, TN
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Houston, Texas 77004
993
mi
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Houston, TX
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6410 Fannin Street
Houston, Texas 77030
995
mi
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Houston, TX
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Indianapolis, Indiana 46202
?
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Indianapolis, IN
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5901 West Olympic Boulevard
Los Angeles, California 90036
1978
mi
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Los Angeles, CA
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1225 Fish Hatchery Road
Madison, Wisconsin 53715
392
mi
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Madison, WI
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Miami, Florida 33136
996
mi
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Miami, FL
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?
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Murray, UT
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New Hyde Park, New York 11040
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New Hyde Park, NY
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1415 Tulane Avenue
New Orleans, Louisiana 70112
797
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New Orleans, LA
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?
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New York, NY
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481
mi
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New York, NY
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New York, New York 10032
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New York, NY
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Newark, New Jersey 07103
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Newark, NJ
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350 West Thomas Road
Phoenix, Arizona 85013
1661
mi
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Phoenix, AZ
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Plymouth, Minnesota 55446
?
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Plymouth, MN
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Poughkeepsie, New York 12601
?
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Poughkeepsie, NY
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33 Staniford Street
Providence, Rhode Island 02905
619
mi
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Providence, RI
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601 Elmwood Avenue
Rochester, New York 14642
354
mi
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Rochester, NY
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?
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Saint Louis, MO
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San Antonio, TX
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San Francisco, California 94115
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San Francisco, CA
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649 Harkle Road
Santa Fe, New Mexico 87505
1282
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Santa Fe, NM
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1100 9th Avenue
Seattle, Washington 98101
2006
mi
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Seattle, WA
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908 Jefferson Street
Seattle, Washington 98104
2006
mi
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Seattle, WA
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1800 East 70th Street
Shreveport, Louisiana 71105
789
mi
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Shreveport, LA
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Statesville, North Carolina 28677
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Statesville, NC
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751
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Tulsa, OK
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Washington, District of Columbia 20010
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Washington,
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Wellington, Florida 33414
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Wellington, FL
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