SINF: Peripheral Neuropathy in Cancer Survivors

Peripheral neuropathy is a common problem among cancer patients who have received
chemotherapy treatment. Acupuncture is a technique that may treat symptoms by inserting very
thin, solid, sterile, stainless steel needles into the skin at specific points. Weak
electrical stimulation is also applied to the needles to try to improve the treatment
effects of the acupuncture.

Study Groups:

If you are found to be eligible to take part in this study, you will be randomly assigned
(as in a roll of dice) to 1 of 3 groups. This is done because no one knows if one study
group is better, the same, or worse than the other group.

- If you are in Group 1, you will have will have acupuncture sessions with electrical
stimulation 3 times a week for 4 weeks, for a total of 12 sessions. Then, you will take
a 2 week break. After that, you will randomly assigned to receive 12 sessions of
acupuncture with electrical stimulation as before or not have anymore sessions in this
study.

- If you are in Group 2, you will have will have acupuncture sessions without electrical
stimulation 3 times a week for 4 weeks, for a total of 12 sessions. Then, you will take
a 2 week break. After that, you will randomly assigned to receive 12 extra sessions of
acupuncture without electrical stimulation or not have anymore sessions in this study.

- If you are in Group 3, you will have acupuncture sessions 3 times per week over 4 weeks
for a total of 12 sessions. You may or may not have electrical stimulation at these
sessions. These sessions will begin 14 weeks after you enroll.

Study Visits Before the First Acupuncture Session:

You will return to the clinic about 7-10 days after the screening visit. The following tests
will be performed 2 times over a 1-2 week span:

- You will complete 3 questionnaires. The questionnaires will ask about any pain you may
be having, about numbness and tingling you may be having, and about other cancer
symptoms, such as fatigue and appetite changes. In total, these questionnaires should
take 15-20 minutes to complete.

- Your tongue will be checked and you heart rate will be measured. This information will
help the study doctor/acupuncturist learn how your body's organs are functioning
together.

- If you can become pregnant, urine will be collected for a pregnancy test. To take part
in this study, you must not be pregnant.

A series of tests used to check your nerve function will also be performed. In total, it
should take about 1-2 hours to complete these 4 tests. The following nerve function tests
will be performed:

- You will complete hand tasks, such as writing, card turning, picking up small objects,
and stacking). You will also be timed as you insert 25 shaped pegs into a board.

- You will complete 2 balance tests. The first balance test measures how long you can
stand on 1 leg. The second balance test measures your ability to stand up from a chair,
walk about 10 feet, and return back to the chair.

Acupuncture Sessions:

At each session, before you receive the acupuncture, your tongue checked and your heart rate
will be measured.

Your first acupuncture session may be on the same day as some of the tests described above,
if possible. If not, it will be scheduled for another day no more than 14 days after the
screening visit, unless you are in Group 3.

For each session, you will be placed in a comfortable position and the study
doctor/acupuncturist will find points on your body where the needles will be placed. All
study participants will have the needles placed at the same points on the body (the hands,
feet, legs, abdomen, and scalp).

Very thin, solid, sterile, stainless steel needles will be used. All of the needles are
specially made for acupuncture. The depth of the needle in the skin and the number of
needles used is based on standard acupuncture procedures. The needles will remain in place
for about 20 minutes.

Electrical stimulation will be added to some of the needles on your feet and hands. This
involves placing wires on the needles, which are connected to a machine that delivers a weak
electrical current through the wires. The strength of the electrical current will be changed
slowly until it is at a comfortable level for you.

Most acupuncture sessions will last about 1 hour. On the weeks that you complete the
questionnaires, it will add about 15-20 minutes.

After your 6th and 12th acupuncture sessions, you will complete the same 3 questionnaires as
you did at the beginning of the study.

Length of Study:

You may take part in this study for up to 28 weeks. If intolerable side effects or symptoms
occur, you will be taken off study early.

End-of-Study Visit:

At the end of the study, or if you go off study early for any reason, you will have an
end-of-study visit. If the doctor thinks it is needed, the following procedures will be
performed within 4 weeks after your last acupuncture session:

- You will complete the same 3 questionnaires as before.

- The 4 nerve tests will be repeated in order to learn if there have been any changes in
your nerve function.

- Your tongue will be checked and your heart rate will be measured.

Additional Information:

During the study, you may still receive your regular pain treatments. You should tell the
study doctor if you want to change your dose or want to start any new drugs for the
treatment of your neuropathy.

If you were in Group 2 or 3, after your participation on this study is complete, you may
receive 3 extra acupuncture treatments.

This is an investigational study. The acupuncture needles used in this study are
commercially available and FDA approved. It is considered investigational to use acupuncture
to treat peripheral neuropathy related to chemotherapy.

Up to 120 patients will take part in this multicenter study. Up to 60 will be enrolled at MD
Anderson.

Inclusion Criteria:

1. Patients must have the ability to understand English, Mandarin, or Taiwanese.

2. Sign a written informed consent document.

3. Willing to follow protocol requirements.

4. Age 18 and older.

5. History of diagnosis of cancer.

6. Patients must have neuropathy greater or equal to 2 according to CTCAE v 4.0 scale
despite previous treatment, which may include Neurontin, Cymbalta and/or Lyrica.
Patients receiving any of these drugs must remain on the same medications throughout
the study period; however, adjustments in dosage are allowed. Patients will be
removed from the study if a change in type of medication is necessary. Patients are
allowed to stop medications but not replace them with other medications

7. The patient's previous chemotherapy treatment must have included a taxane
(paclitaxel, nab-paclitaxel, or docetaxel) or platinum (cisplatin, oxaliplatin, or
carboplatin) and considered the primary cause of the neuropathy by the medical team.

8. ECOG Performance Status of 0, 1, or 2 (Appendix B).

9. Willingness to comply with all study interventions of acupuncture and follow-up
assessments.

Exclusion Criteria:

1. Current active treatment with chemotherapy, radiation or surgery in the past 3 months
or planned treatment during this study protocol period. Hormonal therapy is allowed.

2. Treatment with any neuropathic agent including taxane, platinum, vinca alkaloid, or
bortezumab chemotherapy in the past 6 months.

3. Local infection at or near the acupuncture site. (Although acupuncture is a minimally
invasive procedure, patients will be excluded if there is an indication of
infection.)

4. Physical deformities that could interfere with accurate acupuncture point location.

5. Concurrent use of other alternative medicines such as herbal agents and high dose
vitamins and minerals.

6. Known coagulopathy or taking heparin (including low molecular weight heparin) at full
anti-coagulation doses (prophylaxis is allowed) or Coumadin at any dose. Patients on
aspirin or non-steroidal anti-inflammatories or other antiplatelet medicines will be
allowed to participate.

7. Platelets < 50 H K/UL in the past 30 days.

8. WBCs < 3.0 K/UL or ANC <1,500 K/UL) in the past 30 days.

9. Active CNS disease. (The action for acupuncture may be associated with central
nervous system activity, and patients with CNS pathology may respond differently to
treatment than the general population.)

10. Cardiac pacemaker.

11. Mental incapacitation or significant emotional or psychological disorder that, in the
opinion of the investigators, precludes study entry. (These patients may not be able
to cooperate with this slightly invasive procedure or with the data collection
process.)

12. Currently pregnant. (Certain acupuncture applications have been reported to stimulate
uterine contractions.)

13. History of diabetic neuropathy or neuropathy related to HIV.

14. Previous acupuncture treatment for any indication within 30 days of enrollment.

15. Planned or actual changes in type of medications that could affect symptoms related
to PN. New medications for the treatment of CIPN are not allowed during the study.
Note: Subjects need to be on stable doses of CIPN medications for 4 weeks.

16. Grade III lymphedema or lymphedema considered severe by the treating clinician.