Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Repeat Escalating Doses of GSK1325756 Solution for Infusion, and Absolute Bioavailability Relative of an Oral Dose, in Healthy Adult Subjects

Inclusion Criteria:

- Males/females aged between 18 and 65 years of age inclusive, at the time of signing
the informed consent.

- Healthy as determined by a responsible and experienced physician, based on a medical
evaluation including (medical history, physical examination, laboratory tests and
ECG). A subject with a clinical abnormality or laboratory parameter(s) which is/are
not specifically listed in the inclusion or exclusion criteria, outside the reference
range for the population being studied may be included only if the Investigator
agrees and documents that the finding is unlikely to introduce additional risk
factors and will not interfere with the study procedures

- Body weight >=60 kilograms (kg) for men and >=45 kg for women; and Body Mass Index
(BMI) within the range 19 to 32 kg/square meter (m^2) (inclusive).

- A female subject is eligible to participate if she is of: Non-childbearing potential
defined as pre-menopausal females with a documented tubal ligation or hysterectomy
[for this definition, "documented" refers to the outcome of the
investigator's/designee's review of the subject's medical history for study
eligibility, as obtained via a verbal interview with the subject or from the
subject's medical records]; or postmenopausal defined as 12 months of spontaneous
amenorrhea [in questionable cases a blood sample with simultaneous follicle
stimulating hormone (FSH) > 40 milli-international unit (MIU)/milliliter (mL) and
estradiol <40 picograms (pg)/mL (<147 picomoles [pmol]/liter [L]) is confirmatory].

- Male subjects with female partners of child-bearing potential must agree to use one
of the acceptable contraception methods. This criterion must be followed from the
time of the first dose of study medication until 90 days following the last dose.

- Alanine aminotransferase (ALT), alkaline phosphatase and bilirubin <=1.5 x upper
limit of normal (ULN) (isolated bilirubin >1.5xULN is acceptable if bilirubin is
fractionated and direct bilirubin <35%).

- Based on a single ECG obtained over a brief recording period: corrected QT interval
(QTc) <450 milliseconds (msec); or QTc <480 msec in subjects with Bundle Branch
Block.

- Capable of giving written informed consent, which includes compliance with the
requirements and restrictions listed in the consent form.

Exclusion Criteria:

- Current or chronic history of liver disease, or known hepatic or biliary
abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).

- History of regular alcohol consumption within 6 months of the study defined as:

- An average weekly intake of >14 drinks for males or >7 drinks for females. One drink
is equivalent to 12 grams (g) of alcohol: 12 ounces (360 mL) of beer, 5 ounces (150
mL) of wine or 1.5 ounces (45 mL) of 80 proof distilled spirits.

- History of sensitivity to any of the study medications, or components thereof or a
history of drug or other allergy that, in the opinion of the investigator or
GlaxoSmithKline (GSK) Medical Monitor, contraindicates their participation.

- Part A only: Subjects currently or likely to take antacids (H2 receptor antagonists,
proton pump inhibitors [PPI] blockers, etc.) at any point during the study.

- A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody
result within 3 months of screening.

- Urinary cotinine levels indicative of smoking history or regular use of tobacco- or
nicotine-containing products within 3 months prior to screening.

- A positive pre-study drug/alcohol screen.

- A positive test for human immunodeficiency virus (HIV) antibody.

- Pregnant females as determined by positive (serum or urine) human chorionic
gonadotropin (hCG) test at screening or prior to dosing.

- Subjects with a peripheral blood neutrophil count at the screening visit <2 x 10^9/L.

- Subjects with a history of renal disease or subjects with an abnormal urinalysis
(confirmed on repeat) suggesting the possibility of renal disease (e.g. proteinuria).

- Subjects with a serum creatinine at the screening visit >1 x ULN.

- Where participation in the study would result in donation of blood or blood products
in excess of 500 mL within a 56 day period.

- The subject has participated in a clinical trial and has received an investigational
product within the following time period prior to the first dosing day in the current
study: 30 days, 5 half-lives or twice the duration of the biological effect of the
investigational product (whichever is longer).

- Exposure to more than four new chemical entities within 12 months prior to the first
dosing day