A Compassionate Case Study to Assess the Hypotensive Efficacy of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Glaucoma Patients With Uncontrolled Intraocular Pressure to Avoid Surgical Intervention

Inclusion Criteria:

1. Patients with open-angle glaucoma.

2. IOP above the target range or visual field progression with use of maximum standard
drug therapy.

3. Have given written informed consent, prior to any investigational procedures.

4. Ability to attend for the 6-month duration of treatment.

Exclusion Criteria:

1. Angle-closure glaucoma

2. Eyes having had previous incisional glaucoma surgery

3. Known hypersensitivity to any component of the formulation (benzalkonium chloride,
etc.), or to topical anesthetics.

4. Ocular medication of any kind within 30 days of base-line visit, with the exception
of ocular hypotensive medications and/or lubricating drops for dry eye (which may be
used throughout the study).

5. Any abnormality preventing reliable applanation tonometry of the treated eye.

6. Clinically significant systemic disease (e.g., uncontrolled diabetes, myasthenia
gravis, hepatic, renal, endocrine or cardiovascular disorders) which might interfere
with the study.

7. Participation in any investigational study within the past 30 days.

8. Inability to perform reliable visual field testing.

9. Unwilling to sign the consent form approved by the Institutional Review Board (IRB)
of the New York Eye and Ear Infirmary.

10. Self-reported poor compliance to treatment.

11. Reluctance to return for scheduled follow-up visits.

12. Patients not able to understand the nature of the study.