Incomplete Response in Late-Life Depression: Getting to Remission With Buprenorphine

Up to one half of older patients with major depression develop Late-Life Treatment Resistant
Depression (LL-TRD). Consequences of LL-TRD include suicide, worsened medical conditions,
increased caregiver burden, and higher all-cause mortality. The development and testing of
novel-mechanism pharmacotherapies is a public health priority embraced by National Institute
of Mental Health (NIMH). Among the neuropeptidergic transmitters, opioids are known to
modulate mood, and this system is often altered in patients with major depression. Targeting
the opiate system in LL-TRD may positively modulate a system in which there is age-associated
imbalance between circulating opiates and the density and binding affinity of mu and kappa
opiate receptors. Buprenorphine (BPN) is an antagonist at the kappa opiate receptor and a
partial agonist at the mu opiate receptor. Either, or both, of these pharmacodynamic actions
may underlie its putative antidepressant effects. Our research group has open pilot data from
15 older adults with prospectively demonstrated treatment resistance to venlafaxine who were
exposed to low-dose BPN, suggesting a clinically meaningful antidepressant effect. In
addition, since BPN: 1) is available in sublingual formulation and 2) has a favorable safety
and pharmacokinetic profile, it is an attractive candidate to re-purpose as a molecule for
LL-TRD. Thus, the overarching aims of this project are to examine the feasibility, safety,
tolerability and clinical effect of low-dose BPN as a novel treatment for LL-TRD and to
develop preliminary data about mechanism of action (MOA).

The overarching aims are to examine the feasibility, safety, and tolerability of
buprenorphine (BPN) as a novel treatment for late-life treatment resistant depression
(LL-TRD). This also involves using translational tools of modern neurobiology (fMRI) to
rapidly obtain proof-of-concept support for further clinical development. Formal dosing
schedules in the use of buprenorphine have yet to be thoroughly established. This study hopes
to determine optimal dosing strategies to improve acceptability.

Inclusion Criteria:

1. Age >/= to 50 years.

2. Major depressive disorder (MDD), single or recurrent, as diagnosed by the Structured
Clinical Interview for the DSM IV (SCID-IV).

3. Montgomery-Åsberg Depression Rating Scale (MADRS) >/= to 15.

4. Has or agrees to establish a clinical relationship with primary care physician (PCP).

5. Availability of an informant (e.g., emergency contact).

Exclusion Criteria:

1. Inability to provide informed consent.

2. Depressive symptoms not severe enough i.e.,Montgomery-Åsberg Depression Rating Scale (
MADRS) < 15 at the baseline assessments.

3. Dementia, as defined by The Modified Mini-Mental State (3MS) examination < 84 and
clinical evidence of dementia (e.g., memory impairment, executive dysfunction,
agnosia, apraxia, aphasia, with functional impairment).

4. Lifetime diagnosis of bipolar I or II disorder, schizophrenia, schizoaffective
disorder, schizophreniform disorder, delusional disorder, or current psychotic
symptoms, as diagnosed by the Structured Clinical Interview for DSM (SCID).

5. Abuse of or dependence on alcohol or other substances within the past 3 months as
determined by SCID, and confirmed by study physician interview.

6. Alcohol use amounting to 15 or more drinks per week or drinking 5 or more drinks on
one occasion during any given week.

7. High risk for suicide (e.g., active suicidal ideation (SI) and/or current/recent
intent or plan) AND unable to be managed safely in the clinical trial (e.g., unwilling
to be hospitalized). Urgent psychiatric referral will be made in these cases.

8. Contraindication to venlafaxine extended release (XR) or BPN as determined by study
physician including history of intolerance of either venlafaxine XR or BPN in the
study target dosage range (venlafaxine XR at up to 300 mg/day; BPN at up to 2 mg/day).

9. Inability to communicate in English (i.e., interview cannot be conducted without an
interpreter; subject largely unable to understand questions and cannot respond in
English).

10. Non-correctable clinically significant sensory impairment (i.e., cannot hear well
enough to cooperate with interview).

11. Unstable medical illness, including delirium, uncontrolled diabetes mellitus,
hypertension, or cerebrovascular or cardiovascular risk factors that are not under
medical management. This will be determined based on information from the patient's
personal physician and study physician's clinical judgment. Referral to the patient's
personal physician or to a general practitioner will be made in these cases. Sodium
and glucose levels done in the past 6 months are also reviewed before a subject begins
study medication to determine if an illness is stable or uncontrolled. Individual lab
parameters may deviate from normal without any associated pathophysiology or negative
clinical affect; therefore we will follow the guide below before beginning starting
any study medication.

Sodium value of 135 but asymptomatic= consider to be normal and proceed without
further testing.

Sodium value of 134= repeat sodium. If value continues to be at 134 or higher and
subject is asymptomatic, continue study participation but recheck sodium level after
one week of exposure to study medication to confirm it has stayed stable.

Sodium value of 133 or less= will evaluate subject's medication list to suggest
possibly removing other medications which may be contributing to low sodium (in
collaboration with their PCP), suggest fluid restriction and require repeat sodium
that is normal range prior to commencing study.

Glucose < 275 and asymptomatic= stable to proceed but will communicate value to PCP
with participants permission.

(see exclusion #17 for information on hepatic function lab parameters)

12. Subjects taking psychotropic medications that cannot be safely tapered and
discontinued prior to study initiation. The following exceptions are allowed if they
have been taken at a stable dose for at least 4 weeks prior to study entry and there
is not a plan to change the dose during the next 28 weeks: benzodiazepines up to 2
mg/d lorazepam equivalent; other sedative-hypnotics (e.g., zolpidem, zaleplon,
eszopiclone); gabapentin if prescribed for non-psychiatric indication (e.g.,
neuropathy).

13. History of opiate abuse or dependence.

14. Severe pain, defined as >/= 7 on 0-10 numeric rating scale for pain.

15. Concomitant use of strong or moderate CYP3A4 inhibitor (indinavir, nelfinavir,
ritonavir, clarithromycin, itraconazole, ketonazole, nefazodone, saquinovir,
telithromycin, aprepitant, erythromycin, fluconazole, grapefruit juice, verapamil,
diltiazem)

16. Refusal to stop all opioids (to avoid precipitating opioid withdrawal).

17. Hepatic impairment- aspartate aminotransferase (AST) /alanine aminotransferase (ALT) >
1.5 times upper normal. If AST and ALT are within 1.5 times the upper limit, and
subjects are asymptomatic, they will be considered medically stable to participate

18. Estimated Glomerular Filtration Rate (GFR) < 20 ml/min.

19. Inability/refusal to identify a person as an emergency contact.

20. Pregnancy

21. Contraindications to MRI