Measurement of Distinct Biological Pools of Hydrogen Sulfide in Women With Cardiovascular Disease
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 40 - Any |
| Updated: | 4/2/2016 |
| Start Date: | September 2013 |
| End Date: | August 2014 |
| Contact: | Saurabh Rajpal, MBBS, MD |
| Email: | rajpalsrbh@gmail.com |
| Phone: | 318-675-5941 |
Cardiovascular disease which includes coronary artery disease and peripheral artery disease
remains the leading cause of death among women in the United States. The impact of
cardiovascular in women was not recognized by clinicians for a long time. It is now evident
that, women suffer the consequences of cardiovascular at rates at least as high as those
observed in men but there are still major gaps in our understanding this disease in women.
Hydrogen sulfide (H2S), a gaseous mediator plays an important role in the cardiovascular
system. Research has demonstrated it's critical role in animal ischemia reperfusion models.
Hydrogen sulfide exists in distinct biological pools in blood. Recently, the Kevil lab has
pioneered the development of new analytical techniques for accurate measurement of all
biological pools of H2S. By measuring these distinct pools of H2S in women with and without
cardiovascular disease the investigators hope to further understanding of role of H2S in
pathophysiology of cardiovascular disease. This research will help to assess the ability of
H2S and its distinct biological pools to potentially be a diagnostic marker or a therapeutic
target for cardiovascular disease.
remains the leading cause of death among women in the United States. The impact of
cardiovascular in women was not recognized by clinicians for a long time. It is now evident
that, women suffer the consequences of cardiovascular at rates at least as high as those
observed in men but there are still major gaps in our understanding this disease in women.
Hydrogen sulfide (H2S), a gaseous mediator plays an important role in the cardiovascular
system. Research has demonstrated it's critical role in animal ischemia reperfusion models.
Hydrogen sulfide exists in distinct biological pools in blood. Recently, the Kevil lab has
pioneered the development of new analytical techniques for accurate measurement of all
biological pools of H2S. By measuring these distinct pools of H2S in women with and without
cardiovascular disease the investigators hope to further understanding of role of H2S in
pathophysiology of cardiovascular disease. This research will help to assess the ability of
H2S and its distinct biological pools to potentially be a diagnostic marker or a therapeutic
target for cardiovascular disease.
Inclusion Criteria:
1. Patients presenting to the cardiac catheterization laboratory for coronary or
peripheral angiography.
2. Females,Age>40years
Exclusion Criteria:
1. Inability to provide informed consent.
2. STelevationmyocardialinfarction.
3. Cardiogenicshock.
3. ABI >1.4 (indicative of non-compressible vessel needing further evaluation to diagnose
PAD), unless documented known PAD. 4. Non-atheroscleroticPAD(e.g.Buerger'sdisease). 5.
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