Addition of Excimer Laser to Treatment With Acitretin Tablets for Psoriasis of the Palms and Soles
| Status: | Completed |
|---|---|
| Conditions: | Psoriasis |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/7/2015 |
| Start Date: | June 2014 |
| End Date: | December 2014 |
| Contact: | Yasaman Mansouri, MD |
| Email: | yasaman.mansouri@mssm.edu |
| Phone: | 212-241-3288 |
Addition of 308-nm Excimer Laser to Acitretin Therapy in the Management of Palmoplantar Psoriasis
Psoriasis is a common skin disease that can affect 1-3% of the population. For more severe
psoriasis, oral medication such as acitretin is sometimes given. While acitretin may be
sufficient for treatment of some patients, psoriasis of the palms and soles is particularly
challenging to treat, and may not respond to acitretin alone.
In this study, the focus is on patients who have psoriasis of the palms and soles, and are
currently taking acitretin. The aim is to initially recruit 10 patients and offer them
treatment with a laser, the excimer laser, to one palm and one sole. Patients will receive
laser treatment twice weekly for a total of 8 weeks, while also taking their acitretin
tablet. If the side treated with the excimer laser shows greater improvement compared to the
other side, the second part of the study will be conducted.
In this second part, another 15 patients will be included. These patients will receive twice
weekly treatments with the excimer laser to one both palms and/or soles, for a total of 8
weeks. The aim is to prove that the addition of excimer laser to treatment with acitretin
will lead to greater improvement of psoriasis on palms and soles.
psoriasis, oral medication such as acitretin is sometimes given. While acitretin may be
sufficient for treatment of some patients, psoriasis of the palms and soles is particularly
challenging to treat, and may not respond to acitretin alone.
In this study, the focus is on patients who have psoriasis of the palms and soles, and are
currently taking acitretin. The aim is to initially recruit 10 patients and offer them
treatment with a laser, the excimer laser, to one palm and one sole. Patients will receive
laser treatment twice weekly for a total of 8 weeks, while also taking their acitretin
tablet. If the side treated with the excimer laser shows greater improvement compared to the
other side, the second part of the study will be conducted.
In this second part, another 15 patients will be included. These patients will receive twice
weekly treatments with the excimer laser to one both palms and/or soles, for a total of 8
weeks. The aim is to prove that the addition of excimer laser to treatment with acitretin
will lead to greater improvement of psoriasis on palms and soles.
Inclusion Criteria:
- Male or female subject at least 18 years of age
- Diagnosis of psoriasis, with palmoplantar involvement
- Initiated on oral acitretin for treatment of their psoriasis by their physician
Exclusion Criteria:
- Subjects less than 18 years old
- Subjects with any skin disease, disease state, or physical condition that would
impair evaluation of the skin
- Additional systemic therapy for psoriasis in last 4 weeks
- Additional topical or photo-therapy in last 2 weeks
- Usage of any additional therapy except for emollients and keratolytic agents (5%
salicylic acid ointment or 30% urea cream)
- Pre-existent or current cutaneous malignancy affecting the palms and/or soles
- History of photosensitive disorders
- Ingestion of drugs reported to cause photosensitivity reactions
- Presence of erythroderma or generalized pustular psoriasis
- Concomitant use of sunlamps
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Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai is...
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