SC2i Tissue and Data Repository Protocol

Inclusion Criteria:

- Patients with injury or illness requiring surgical care or treatment in a critical
care or emergency setting who are being cared for at SC2I sites (Grady Memorial
Hospital, Emory Univeristy Hospital, and Duke University Health Systems)

- Healthy volunteer control subjects to include individuals without any known injury or
end-stage organ disease and patients who have recovered from prior injury.

- Ability to understand the purposes and risks of the study and willingly give written
informed consent, or in the case of incapacitated patients, a willing surrogate able
to give written informed consent.

Exclusion Criteria:

- Any condition that, in the opinion of the attending physician, would place the patient
or volunteer subject at undue risk by participating. Specific conditions include but
are not limited to anemia prohibitive of phlebotomy, coagulopathy, or technical
considerations that would prevent acquisition of sufficient tissue or fluid for
clinical use. Acquisition of samples from patients requiring active transfusion or
with transfusion-associated coagulopathy will be considered as appropriate study
candidates at the discretion of the attending physician.