Caffeine Disposition After Inhalation
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 21 - 45 |
| Updated: | 10/28/2017 |
| Start Date: | July 2014 |
| End Date: | March 20, 2017 |
Pharmacokinetics and Pharmacodynamics of a 100 mg Caffeine Dose After Oral Consumption of an Energy Drink or Inhalation Using the Aeroshot Administration Device
The purpose of this study is to determine how fast caffeine gets into your body with a
product called Aeroshot™. Aeroshot™ is a lipstick sized device that you slide open and then
put your mouth over the opening and inhale. A fine powder containing 100 mg of caffeine is
deposited on your tongue and the inside of your mouth. Caffeine will be absorbed through the
membranes in your mouth or swallowed and then absorbed in your stomach. We will compare the
absorption of caffeine after using the Aeroshot™ with the absorption after drinking an energy
drink by taking 15 blood samples over 8 hours and measuring the caffeine levels in your
blood. You will also be asked to fill out some scales to measure the effects you feel after
the caffeine dose. We hypothesize that caffeine absorption after inhalation will be faster
than after an energy drink.
product called Aeroshot™. Aeroshot™ is a lipstick sized device that you slide open and then
put your mouth over the opening and inhale. A fine powder containing 100 mg of caffeine is
deposited on your tongue and the inside of your mouth. Caffeine will be absorbed through the
membranes in your mouth or swallowed and then absorbed in your stomach. We will compare the
absorption of caffeine after using the Aeroshot™ with the absorption after drinking an energy
drink by taking 15 blood samples over 8 hours and measuring the caffeine levels in your
blood. You will also be asked to fill out some scales to measure the effects you feel after
the caffeine dose. We hypothesize that caffeine absorption after inhalation will be faster
than after an energy drink.
Inclusion Criteria:
- healthy volunteer
- non-smoker
Exclusion Criteria:
- Take chronic medication
- Co-existing diseases
- Platelet count less than 100,000/uL (per microliter)
- Acute or chronic psychiatric condition
- Consume more than 300 mg of caffeine per day
- Participated in another study within last 30 days or donated blood in last 6 weeks
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