Activity To Improve Outcomes in Peripheral Arterial Disease
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 21 - 90 |
| Updated: | 7/13/2018 |
| Start Date: | August 2014 |
| End Date: | August 2020 |
Peripheral artery disease (PAD) results in blockages of arteries (blood vessels) in the legs
and decreased blood flow to the legs. This may cause difficulty or pain with walking or other
activities that use leg muscles. Exercise may help improve blood flow in the legs and improve
the ability to walk. This research project is being implemented in adults with PAD to examine
the effects of exercise or weight loss programs on lower extremity blood flow, health, and
physical function.
and decreased blood flow to the legs. This may cause difficulty or pain with walking or other
activities that use leg muscles. Exercise may help improve blood flow in the legs and improve
the ability to walk. This research project is being implemented in adults with PAD to examine
the effects of exercise or weight loss programs on lower extremity blood flow, health, and
physical function.
This pilot study seeks to gather data on different exercise interventions in PAD.
Collectively, the proposed studies will gather data on the role of novel exercise
interventions in those with PAD who are receiving conservative treatment as well as those who
have undergone an endovascular intervention for lower extremity arterial disease.
We hypothesize that patients who undergo an exercise intervention will: A) show improved
lower extremity perfusion and B) improve their functional ability, compared to a standard
care control group over 6 months of follow-up. We further hypothesize that these improvements
are mediated through angiogenesis and increased perfusion of the lower limb, as well as
improvements in muscle strength, mass, and function.
Collectively, the proposed studies will gather data on the role of novel exercise
interventions in those with PAD who are receiving conservative treatment as well as those who
have undergone an endovascular intervention for lower extremity arterial disease.
We hypothesize that patients who undergo an exercise intervention will: A) show improved
lower extremity perfusion and B) improve their functional ability, compared to a standard
care control group over 6 months of follow-up. We further hypothesize that these improvements
are mediated through angiogenesis and increased perfusion of the lower limb, as well as
improvements in muscle strength, mass, and function.
Inclusion Criteria:
- Age 21-90 years
- Ankle brachial index < 0.9
Exclusion Criteria:
- Cancer under active treatment, except prostate, skin, and hematologic cancers
- Planned for open lower extremity bypass surgery
- Body mass index >45
- Lower extremity gangrene
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