ALA-induced PpIX Fluorescence During Brain Tumor Resection
| Status: | Recruiting |
|---|---|
| Conditions: | Brain Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 4/3/2019 |
| Start Date: | July 2014 |
| End Date: | July 2021 |
| Contact: | Keith Paulsen, PhD |
| Email: | Keith.Paulsen@Dartmouth.EDU |
| Phone: | 603-646-2695 |
Quantification of ALA-induced PpIX Fluorescence During Brain Tumor Resection
Removing a tumor from a patients brain is hard to do because, very often, brain tumors do not
have boundaries that are easy for the patients surgeon to find. In many cases, the surgeon
can't tell exactly where the tumor begins or ends. The surgeon usually can remove most of the
patient's tumor by looking at the MRI images that were taken of the patient's brain before
surgery. However, the surgeon does not have any good way to tell if the entire tumor has been
removed or not. Removing the entire tumor is very important because leaving tumor behind may
allow it to grow back which could decrease the chances of survival.
have boundaries that are easy for the patients surgeon to find. In many cases, the surgeon
can't tell exactly where the tumor begins or ends. The surgeon usually can remove most of the
patient's tumor by looking at the MRI images that were taken of the patient's brain before
surgery. However, the surgeon does not have any good way to tell if the entire tumor has been
removed or not. Removing the entire tumor is very important because leaving tumor behind may
allow it to grow back which could decrease the chances of survival.
Inclusion Criteria:
- Preoperative diagnosis of either presumed first-time low or high grade glioma, or
recurrent glioma, or metastasis, or meningioma
- Tumor judged to be suitable for open cranial resection based on preoperative imaging
studies.
- Patient or LAR able to provide written informed consent.
- No serious associated psychiatric illnesses.
- Age > 21 years old.
Exclusion Criteria:
- Pregnant women or women who are breast feeding
- History of cutaneous photosensitivity, porphyria, hypersensitivity to porphyrins,
photodermatosis, exfoliative dermatitis.
- History of liver disease within the last 12 months.
- Elevated liver function levels greater than 2.5 times the normal limit from laboratory
tests conducted within 30 days prior to surgery.
- Inability to comply with the photosensitivity precautions associated with the study.
- Plasma creatinine in excess of 180umol/L within 30 days prior to surgery
We found this trial at
1
site
1 Medical Center Dr
Lebanon, New Hampshire 03756
Lebanon, New Hampshire 03756
(603) 650-5000
Principal Investigator: David W Roberts, MD
Phone: 603-650-4607
Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock is a national leader in patient-centered health care and building...
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