Computer-delivered Screening & Brief Intervention for Marijuana Use in Pregnancy

There are at present no evidence-based interventions for marijuana use during pregnancy,
despite its being by far the most commonly used illicit drug during pregnancy (particularly
among African-American women), and despite growing evidence that it may have a range of
long-term cognitive and neurobehavioral consequences. This R34 clinical trial planning grant
therefore proposes the development and preliminary validation of two high- reach and mutually
compatible technology-based interventions for marijuana use during pregnancy. The first, a
theory-based, synchronous, and highly interactive computer-delivered brief intervention, will
be based on an emerging knowledge base regarding key elements of efficacious
technology-delivered interventions. The second intervention, a series of tailored text
messages, will build on the rich literature regarding key tailoring elements. These
interventions will be developed and refined with input from pregnant women who report active
use of marijuana, as well as from health care providers. They will subsequently be
tested-alone and in combination-in a pilot randomized trial involving 80 women actively using
marijuana during pregnancy. This Stage I pilot work would set the stage for a confirmatory
Stage II trial. It would also produce the first high-reach brief interventions for marijuana
use during pregnancy. If effective, these approaches could have a substantial population
impact on marijuana use among pregnant women, with potential for lifelong improved outcomes
for both mother and child.

Inclusion Criteria:

- 18 to 40 years of age

- 20 weeks or less gestation

- intention to carry pregnancy to term

- self-reported marijuana use in month before pregnancy

- own a cell phone and willingness to receive text messages

- gives consent to access medical records for collection of birth outcome data

Exclusion Criteria:

- frank cognitive impairment or psychosis

- not able to communicate in English

- not planning to deliver at a Detroit Medical Center (DMC) hospital

- previous or current participant in a study conducted by Dr. Ondersma

- Eunice Kennedy Shriver National Institute of Child Health and Human Development
(NICHD) Perinatal Research Branch participant.