RAMP 200 / RAMP Cardiovascular Tests at the Point-of-Care

Inclusion Criteria:

Study Arms A - Troponin I (ACS/MI)

1. Males or Females, 18 years of age or older, of any race

2. Has had a routine test order of Troponin for suspected Acute Coronary Syndrome /
Myocardial Infarction (ACS/MI) - as per institutional guidelines

3. Willing to voluntarily agree to sign a consent form (if applicable)

Study Arms B - Myoglobin (ACS/MI)

1. Males or Females, 18 years of age or older, of any race

2. Has had a routine test order of Troponin for suspected Acute Coronary Syndrome /
Myocardial Infarction (ACS/MI) - as per institutional guidelines

3. Myoglobin test result falls within the reportable range of the test as reported in
the RAMP® Myoglobin IFU.

4. Willing to voluntarily agree to sign a consent form (if applicable)

Study Arms C - CK-MB (ACS/MI)

1. Males or Females, 18 years of age or older, of any race

2. Has had a routine test order of Troponin for suspected Acute Coronary Syndrome /
Myocardial Infarction (ACS/MI) - as per institutional guidelines

3. CK-MB test result falls within the reportable range of the test as reported in the
RAMP® CK-MB IFU.

4. Willing to voluntarily agree to sign a consent form (if applicable)

Study Arm D - NT-proBNP (HF)

1. Males or Females, 18 years of age or older, of any race

2. Has had a routine test order of NT-proBNP or BNP for suspected Heart Failure (HF) -
as per institutional guidelines

3. Willing to voluntarily agree to sign a consent form (if applicable)

Exclusion Criteria:

Study Arms A, B, C - Troponin I, Myoglobin, CK-MB (ACS/MI)

1. Healthy Subjects

2. Pregnant or lactating

3. Subjects not having a cardiac marker test ordered

4. Blood sample collected >24 hours prior to screening

5. Subjects without adequate volumes of surplus EDTA whole blood available for all
required trial testing

6. Non-compliance to the protocol or the inclusion criteria

Study Arm D - NT-proBNP (HF)

1. Healthy Subjects

2. Pregnant or lactating

3. Subjects not having a cardiac marker test ordered

4. Blood sample collected >24 hours prior to screening

5. Subjects without adequate volumes of surplus EDTA whole blood available for all
required trial testing

6. Non-compliance to the protocol or the inclusion criteria