Physical Activity Intervention for Older Patients During Chemotherapy for Colorectal Cancer

The primary purpose of this multicenter, randomized controlled study is to evaluate the
impact of a physical activity program on fatigue in older patients (≥60 years) undergoing
adjuvant chemotherapy for colorectal cancer. The investigators also plan to evaluate physical
function and quality of life as secondary objectives. The investigators' hypotheses are that
people who undergo the physical activity intervention compared to those who do not, will: 1)
report less fatigue, 2) report higher health related quality of life, and 3) have less
decline in physical function. Additionally, The investigators will characterize ≥grade 3
adjuvant chemotherapy associated toxicities in this older population, and describe the
changes reported in fatigue, physical function, and HRQOL over the course of chemotherapy.

Inclusion Criteria:

- ≥ Age 60 years (no upper age limit)

- Diagnosis of stage II-III colon or rectal cancer planned for treatment with adjuvant
chemotherapy scheduled as part of standard treatment

- Able to read English (required for CGA and other surveys administered)

- Approval from their treating physician to engage in moderate-intensity physical
activity

- Patient-assessed ability to walk and engage in moderate physical activity

- Signed, IRB-approved written informed consent

Exclusion Criteria:

- Other active, invasive malignancy requiring ongoing therapy or expected to require
systemic therapy

- Already walking or engaging in other physical activity >120 minutes per week as
documented via subject self-report

- Unable to walk or engage in moderate-intensity physical activity

- One or more significant medical conditions that in the physician's judgment preclude
participation in the walking intervention