A Study of LY2951742 in Participants With Mild to Moderate Osteoarthritis Knee Pain

Inclusion Criteria:

- Have osteoarthritis (OA) of the knee joint based on American College of Rheumatology
(ACR) criteria and confirmed with X-rays and ACR functional class of I to III

- Have been on stable dose of prescription Nonsteroidal Anti-Inflammatory Drugs
(NSAIDS), celecoxib, tramadol, or acetaminophen of at least 2000 mg per day for at
least 20 days in the past month

- Willing to stop all analgesics for OA pain during the study

- Experienced pain while walking in the target knee of 50-90 mm inclusive on 0-100
Visual Analog Scale (VAS) with an increase in pain while walking of at least 10 mm
following washout of current Osteoarthritis pain medications at screening

Exclusion Criteria:

- Allergic to LY2951742, celecoxib, other NSAIDS, including aspirin, and similar drugs

- Arthritis of the knee from other causes

- Uncontrolled hypertension

- Have OA pain that requires treatment with potent opioids, systemic corticosteroids,
intra-articular injections, duloxetine, or venlafaxine

- Moderate to severe renal impairment

- Pregnant or lactating