Dietary Methionine and Cysteine Restriction in Healthy Adults
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 24 - 65 |
| Updated: | 8/1/2018 |
| Start Date: | June 2014 |
| End Date: | July 2017 |
Studies in laboratory models indicate that dietary methionine restriction (MR) enhances
longevity and produces short- and long-term metabolic changes that are consistent with a
healthy lifespan. The present study was designed to establish levels of dietary methionine or
methionine and cysteine that induce physiological changes in healthy adults like those
observed in rodent studies .
longevity and produces short- and long-term metabolic changes that are consistent with a
healthy lifespan. The present study was designed to establish levels of dietary methionine or
methionine and cysteine that induce physiological changes in healthy adults like those
observed in rodent studies .
In this controlled feeding study, subjects will be randomized to one of two experimental.
Group A (N=10): will start with control diet (31 mg/kg/day Met; 31 mg/kg/day Cys) for 4 weeks
followed by a washout for 3-4 weeks, then a 70% MR diet (9.3 mg/kg/day Met; 40.3 mg/kg/day
SAA) for 4 weeks, followed by 3-4 weeks washout period and then a 90% MR diet (3.1 mg/kg/day
Met; 34.1 mg/kg/day SAA) for 4 weeks. Group B (N=10): will start with control diet (31
mg/kg/day Met; 31 mg/kg/day Cys) for 4 weeks followed by a washout for 3-4 weeks then a 50%
methionine and cysteine restricted (M/CR) diet (15.5 mg/kg/day Met; 15.5 mg/kg/day Cys; 31
mg/kg/day SAA), followed by 3-4 weeks washout period and then a 65% M/CR diet (10.8 mg/kg/day
Met; 10.8 mg/kg/day Cys; 21.6 mg/kg/day SAA) for 4 weeks.
Group A (N=10): will start with control diet (31 mg/kg/day Met; 31 mg/kg/day Cys) for 4 weeks
followed by a washout for 3-4 weeks, then a 70% MR diet (9.3 mg/kg/day Met; 40.3 mg/kg/day
SAA) for 4 weeks, followed by 3-4 weeks washout period and then a 90% MR diet (3.1 mg/kg/day
Met; 34.1 mg/kg/day SAA) for 4 weeks. Group B (N=10): will start with control diet (31
mg/kg/day Met; 31 mg/kg/day Cys) for 4 weeks followed by a washout for 3-4 weeks then a 50%
methionine and cysteine restricted (M/CR) diet (15.5 mg/kg/day Met; 15.5 mg/kg/day Cys; 31
mg/kg/day SAA), followed by 3-4 weeks washout period and then a 65% M/CR diet (10.8 mg/kg/day
Met; 10.8 mg/kg/day Cys; 21.6 mg/kg/day SAA) for 4 weeks.
Inclusion Criteria:
- Healthy English speaking male and female volunteers
- May or may not be students
- Age range 24-65 years
- Subjects will need to be of normal weight or moderately overweight (BMI 18.5-35 kg/m2)
- Subjects will be non-smokers
Exclusion Criteria:
- No use of medications known to impact the biomarkers of interest
- Pregnancy and lactating women
- Persons with documented diabetes
- No use of high dose dietary antioxidant supplements or fish oil/flax seed oil for
n-acetylcysteine for at least 1 month prior to the study
- Use of tobacco products over the past 6 months
- Unstable weight
- Individuals with allergies to eggs, wheat, nuts, soy and latex
- Individuals with phenylketonuria (PKU)
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