Combined Medication for Improved Analgesia in Superficial Pain
| Status: | Completed |
|---|---|
| Conditions: | Chronic Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 7/5/2018 |
| Start Date: | April 2014 |
| End Date: | June 2017 |
Potential for Improved Analgesia From Combined Medication for Superficial Pain
This research study is being done to assess if a combination of medications can enhance the
relief of superficial pain (pain at the surface of the skin, such as sunburn pain). The
investigators also want to find out if certain genes may be linked to individual differences
in experienced efficacy of pain killers. The combination of medications under investigation
is diclofenac and atropine. Diclofenac has been approved by the U.S. Food and Drug
Administration (FDA) to treat pain. Atropine has been approved by the FDA to treat certain
types of poisoning, heartbeat problems, and other diseases but atropine is not approved to
treat pain. However, atropine has been used for many years in different European countries to
treat painful conditions such as stomach cramps.This research study will compare diclofenac
and atropine to placebo.
relief of superficial pain (pain at the surface of the skin, such as sunburn pain). The
investigators also want to find out if certain genes may be linked to individual differences
in experienced efficacy of pain killers. The combination of medications under investigation
is diclofenac and atropine. Diclofenac has been approved by the U.S. Food and Drug
Administration (FDA) to treat pain. Atropine has been approved by the FDA to treat certain
types of poisoning, heartbeat problems, and other diseases but atropine is not approved to
treat pain. However, atropine has been used for many years in different European countries to
treat painful conditions such as stomach cramps.This research study will compare diclofenac
and atropine to placebo.
Inclusion Criteria:
- Male and female healthy volunteers.
- 18-40 years of age.
- Ability to read and understand English; English can be a second language provided that
the participant feels that he/she understand all the questions used in the assessment
measures.
Exclusion Criteria:
- Chronic pain condition or chronic or current treatment with any pain medication.
- Presence of any illness or medication use that is judged to interfere with the trial.
For example: psychiatric disorder, medication that can influence cognition or
emotional processing, i.e. sleep medication, antidepressants, anti-convulsants or
opioids.
- Unwillingness to receive brief pain stimulation administered by a heat probe on the
hand.
- Allergy or contra-indication to receiving nonsteroidal anti-inflammatory medication
and atropine (Treatment with antidepressants, neuroleptics, antihistaminic, levodopa,
anti-acids. Pregnancy, breast-feeding, myasthenia gravis, pyloric stenosis,
gastro-esophageal reflux, gastric ulcer, constipation, prostatic enlargement,
glaucoma, cardio-pulmonary condition -including tachycardia, arrhythmia,
arteriosclerosis-, hyperthyroidism, high blood pressure, genetic disease, kidney
failure)
We found this trial at
1
site
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
Click here to add this to my saved trials
