Basic Research Study to Examine the Relation Between Muscle Insulin Resistance and Lipid Production in the Liver.
| Status: | Completed |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 10/25/2017 |
| Start Date: | November 2007 |
| End Date: | September 2017 |
Lipid and Carbohydrate Metabolism: Effects of Exercise
The purpose of this study is to examine the pathophysiology of insulin resistance and the
relation to the metabolic syndrome in humans.
relation to the metabolic syndrome in humans.
In this study insulin resistant (IR), young offspring of parents with type 2 diabetes (18-46
years) and healthy, lean elderly individuals (65-90 years) will undergo 1H/13C MRS
measurements of liver and muscle lipid and glycogen content before and after a high
carbohydrate meal challenge. Hepatic de novo lipogenesis will be determined as the
incorporation of deuterium, from deuterium labeled water (2H2O), into plasma triglycerides 5.
These metabolic studies will be performed in 3 sets: Study Part 1: Resting, Study Part 2:
After 1 bout of exercise and Study part 3: After 6 weeks of exercise training. Since
intra-abdominal obesity has been postulated to be at the core of the metabolic derangements
and directly responsible for the atherogenic dyslipidemia associated with the metabolic
syndrome, the investigators will also measure intra-abdominal fat content by magnetic
resonance imaging (MRI).
years) and healthy, lean elderly individuals (65-90 years) will undergo 1H/13C MRS
measurements of liver and muscle lipid and glycogen content before and after a high
carbohydrate meal challenge. Hepatic de novo lipogenesis will be determined as the
incorporation of deuterium, from deuterium labeled water (2H2O), into plasma triglycerides 5.
These metabolic studies will be performed in 3 sets: Study Part 1: Resting, Study Part 2:
After 1 bout of exercise and Study part 3: After 6 weeks of exercise training. Since
intra-abdominal obesity has been postulated to be at the core of the metabolic derangements
and directly responsible for the atherogenic dyslipidemia associated with the metabolic
syndrome, the investigators will also measure intra-abdominal fat content by magnetic
resonance imaging (MRI).
Inclusion Criteria:
- Body Mass Index < 29 kg/m2
- No regular exercise routine
- Non-smokers
- Absence of systemic and organ disease.
Exclusion Criteria:
- Hematocrit < 35 vol%
- History of claustrophobia
- Ferromagnetic implants
- Regular exercise regimen
- Not weight stable
- Any significant hematological, neurological, musculoskeletal or endocrine disease
(including diabetes mellitus)
- Any significant cardiovascular condition, including confirmed CAD and prior
cardiovascular events
- Taking coumadin as anticoagulant therapy.
We found this trial at
1
site
New Haven, Connecticut 06520
Principal Investigator: Kitt Petersen, MD
Phone: 203-688-4106
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