Adaptation in Polyphenol Bioavailability and Bioactivity During Long Term Exposure to Polyphenol-Rich Foods

Exclusion Criteria:

- Younger than 25 years old or older than 75 years old

- Use of blood-thinning medications such as Coumadin (warfarin), Dicumarol (dicumarol),
or Miradon (anisindione)

- Presence of any gastrointestinal disease, metabolic disease, bariatric surgery, or
malabsorption syndromes that may interfere with the study goals

- Have been pregnant during the previous 12 months, are currently pregnant or
lactating, or plan to become pregnant during the study

- Type 2 diabetes requiring the use of oral antidiabetic agents or insulin

- Fasting triglycerides greater than 300 mg/dL

- Fasting glucose greater than 126 mg/dL

- History of eating disorders or other dietary patterns which are not consistent with
the dietary intervention (e.g., vegetarians, very low fat diets, high protein diets)

- Use of prescription or over-the-counter antiobesity medications or supplements (e.g.,
phenylpropanolamine, ephedrine, caffeine) during and for at least 6 months prior to
the start of the study or a history of a surgical intervention for obesity

- Active cardiovascular disease (such as a heart attack or procedure within the past
three months or participation in a cardiac rehabilitation program within the last
three months, stroke, or history/treatment for transient ischemic attacks in the past
three months, or documented history of pulmonary embolus in the past six months).

- Use of any tobacco products in past 3 months

- Unwillingness to abstain from herbal supplements for two weeks prior to the study and
during the study

- Known (self-reported) allergy or adverse reaction to study foods

- Unable or unwilling to give informed consent or communicate with study staff

- Self-report of alcohol or substance abuse within the past twelve months and/or
current acute treatment or rehabilitation program for these problems (Long-term
participation in Alcoholics Anonymous is not an exclusion)