Craving, Binge Eating and Obesity
| Status: | Archived |
|---|---|
| Conditions: | Obesity Weight Loss, Psychiatric, Eating Disorder |
| Therapuetic Areas: | Endocrinology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
Placebo-Controlled Trial of Bupropion for the Treatment of Binge Eating Disorder
This research study is designed to look at the effectiveness of bupropion for reducing binge
eating in overweight persons with binge eating problems. Participants in the study will
receive either bupropion or placebo ("sugar" pill, inactive medication) as an outpatient for
eight weeks. In addition, participants will be given the option to receive 8 weeks of free
behavioral weight loss treatment. This treatment, known to be effective for reducing binge
eating and helping people lose weight, will be administered following the medication phase
and at no cost.
It is expected that compared to placebo, bupropion will produce greater reductions in binge
eating.
The proposed study is an 8-week randomized placebo-controlled trial to test the efficacy of
bupropion in treating overweight women with binge eating disorder (BED). Bupropion is an
antidepressant that has demonstrated efficacy in smoking cessation and some efficacy in
obesity treatment. Since cravings and depressed mood are hypothesized to contribute to binge
eating episodes, bupropion is a promising psychopharmacological agent in treating binge
eating and reducing weight. It is hypothesized that compared to placebo, bupropion will
produce significantly greater reductions in the frequency of binge eating. Secondary goals
are to explore interrelationships between treatment and changes in cravings, frequency of
binge episodes, emotional eating, and weight loss. Following the medication phase of the
trial, all patients will be offered 8 weeks of behavioral weight loss treatment administered
by doctoral-level psychologists specializing in eating disorders and weight management.
We found this trial at
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Yale University School of Medicine Founded in 1810, the Yale School of Medicine is a...
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