Piperacillin/Tazobactam for Bacteremia With Organisms Producing Chromosomally-Encoded AmpC Beta-Lactamase

The following information will be collected: age, sex, occupation, hospital location at the
time of positive culture (ER, medical ward, ICU etc), prior hospitalization, receipt of
outpatient dialysis, home care or other regular medical care (eg, outpatient chemotherapy),
presence of invasive devices, receipt of antibiotics, including their type and whether they
were adequate for the resistance profile of the organism, prior positive microbiologic
cultures, time and location of positive cultures, underlying diseases and severity of
illness, presence of urinary or intravascular devices, recent immunomodulative therapies or
radiation therapy, physical exam findings, laboratory and radiographical data, antimicrobial
usage within 30 days of onset of the infection, microbiological data and resistance patterns,
choice of antibiotics once organism identified, bacteriological outcomes, laboratory results,
demographic information, medications, clinical outcome,gender, height, weight, ethnicity, and
past medical history. We will collect information retrospectively.

Inclusion Criteria:

- Clinical information is collected by chart review of "case" and "control" patients. A
"case" patient is defined as follows:

- One or more blood cultures are positive for E. cloacae, E. aerogenes, C.
freundii, S. marcescens or M. morganii.

- The patient received piperacillin/tazobactam as the initial empiric therapy.

- The organism was susceptible to piperacillin/tazobactam.

- A "control" patient is defined as follows:

- One or more blood cultures are positive for E. cloacae, E. aerogenes, C.
freundii, S. marcescens or M. morganii.

- The patient received a carbapenem or fluoroquinolone antimicrobial as the initial
empiric therapy.

- The organism was susceptible to the empiric regimen.