Effect of Electronic Cigarette Use on Cough Reflex Sensitivity
| Status: | Completed |
|---|---|
| Conditions: | Infectious Disease, Neurology |
| Therapuetic Areas: | Immunology / Infectious Diseases, Neurology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 6/6/2018 |
| Start Date: | July 2014 |
| End Date: | December 2014 |
Although electronic cigarettes (e-cigs) are now widely used, very little information exists
regarding the effect of electronic cigarette use (vaping) on the respiratory system. The aim
of this study is to evaluate the acute effect of one e-cig vaping session (30 puffs 30
seconds apart) on cough reflex sensitivity in healthy adult nonsmokers.
regarding the effect of electronic cigarette use (vaping) on the respiratory system. The aim
of this study is to evaluate the acute effect of one e-cig vaping session (30 puffs 30
seconds apart) on cough reflex sensitivity in healthy adult nonsmokers.
30 adult nonsmokers will have their cough reflex sensitivity measured at baseline, 15 minutes
after an e-cig vaping session, and 24 hours subsequently. One e-cig vaping session will
consist of 30 puffs of an e-cg (Blu) 30 seconds apart, which will deliver the approximate
nicotine amount delivered by one tobacco cigarette. Cough reflex sensitivity, defined as C5,
the concentration of capsaicin inducing 5 or more coughs, is the standard end point of cough
challenge studies.
after an e-cig vaping session, and 24 hours subsequently. One e-cig vaping session will
consist of 30 puffs of an e-cg (Blu) 30 seconds apart, which will deliver the approximate
nicotine amount delivered by one tobacco cigarette. Cough reflex sensitivity, defined as C5,
the concentration of capsaicin inducing 5 or more coughs, is the standard end point of cough
challenge studies.
Inclusion Criteria:
- healthy adults (age18 years and above)
- nonsmokers
Exclusion Criteria:
- previous smoker
- asthma/other respiratory illness
- acute viral upper respiratory tract infection (common cold) in previous 4 weeks
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