TITAN™ Reverse Shoulder System

Inclusion Criteria:

- Subjects with grossly deficient rotator cuff with severe arthropathy or Subjects with
failed joint replacement with grossly deficient rotator cuff

- Subjects with a shoulder joint anatomically and structurally suited to receive the
device

- Subjects at least 21 years of age and skeletally mature at the time of surgery

- Subject provided consent to participate in the clinical study (having signed the
Informed Consent Form)

Exclusion Criteria:

- Subjects without a functional deltoid muscle

- Subjects with active local or systemic infection

- Subjects with inadequate bone stock in the proximal humerus or glenoid fossa for
supporting the components

- Subjects with poor bone quality such as osteoporosis where there could be considerable
migration of the prosthesis and/or a chance of fracture of the humerus or glenoid

- Subjects with muscular, neurologic, or vascular deficiencies that compromise the
affected extremity

- Subjects with known metal allergies

- Subjects are known to be at risk for lost to follow-up, or failure to return for
scheduled visits

- Subjects who are prisoners

- Female subject who are pregnant, nursing, or of childbearing potential while not
practicing effective contraceptive methods