Brain-Behavior Interactions in Tic Suppression
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology, Psychiatric, Psychiatric |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 12 - 18 |
| Updated: | 2/17/2019 |
| Start Date: | July 1, 2017 |
| End Date: | June 2019 |
| Contact: | Jesse Dzombak |
| Email: | conelealab@umn.edu |
| Phone: | 612-273-9302 |
Integrative Examination of Neurobehavioral Mechanisms in Tic Suppression
The purpose of this study is to examine how the brain and environment interact to influence
children's ability to suppress tics using a medical technology called Transcranial Magnetic
Stimulation (TMS).
children's ability to suppress tics using a medical technology called Transcranial Magnetic
Stimulation (TMS).
Objectives: This study will recruit youth with chronic tics. Chronic tics are the most common
movement disorder in children. The goal of the study is to learn how the brain and
environment influence children's ability to suppress tics. Specifically, we want to learn how
tics are influenced by a certain part of the brain called the supplementary motor area (SMA).
This part of the brain is thought to be more active in people with tics. This will be the
first study to look at the relationship between SMA, tic suppression, and urges to tic.
Research Procedures: The study will take place over the course of three days within a week
(about 5 hours total). The study will examine the relationship between the SMA and tic
suppression using a non-invasive medical technology called Transcranial Magnetic Stimulation
(TMS). Participants will have a diagnostic interview, MRI brain scan (used to find the
location of the SMA), and TMS. Participants will be asked to try to suppress tics before and
after TMS. The information that will be collected from participation includes information
about tic symptoms, emotional and behavioral functioning, and brain activity (from MRI brain
images and TMS results).
movement disorder in children. The goal of the study is to learn how the brain and
environment influence children's ability to suppress tics. Specifically, we want to learn how
tics are influenced by a certain part of the brain called the supplementary motor area (SMA).
This part of the brain is thought to be more active in people with tics. This will be the
first study to look at the relationship between SMA, tic suppression, and urges to tic.
Research Procedures: The study will take place over the course of three days within a week
(about 5 hours total). The study will examine the relationship between the SMA and tic
suppression using a non-invasive medical technology called Transcranial Magnetic Stimulation
(TMS). Participants will have a diagnostic interview, MRI brain scan (used to find the
location of the SMA), and TMS. Participants will be asked to try to suppress tics before and
after TMS. The information that will be collected from participation includes information
about tic symptoms, emotional and behavioral functioning, and brain activity (from MRI brain
images and TMS results).
Inclusion Criteria:
- Presence of motor and/or vocal tics for at least one year
- English fluency
Exclusion Criteria:
- Participants with medical conditions that are contraindicated for TMS (history of any
known intracranial pathology, epilepsy or seizures, traumatic brain injury, brain
tumor, stroke, implanted medical devices, current pregnancy or girls of childbearing
age not using effective contraception, or any other serious medical conditions
- Left-handedness
- Previous diagnosis of psychosis, autism spectrum disorder, mental retardation, or
cognitive disability
- Inability to undergo MRI
- Substance abuse or dependence within the past year
- History of ≥3 sessions of Habit Reversal Therapy or other treatment primarily
comprised of tic suppression strategies
- Current suicidal intent
- Current neuroleptic medications, as these medications are known to lower seizure
threshold
We found this trial at
1
site
Minneapolis, Minnesota 55455
(612) 625-5000
Principal Investigator: Christine Conelea, PhD
Phone: 612-273-9302
Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...
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