The Effects of Hydromorphone on Responses to Verbal Tasks
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 10/11/2018 |
| Start Date: | January 2015 |
| End Date: | September 2016 |
In this study, the investigators will examine the effects of hydromorphone, as compared to
placebo, upon physiological, subjective, and hormonal responses to a stressful speech task
and a non-stressful control task in healthy adults. There is strong evidence in support of
the role of endogenous opioids and opiates in mediating social behavior in humans and other
animals, and particularly, in social distress. The investigators have recently shown that
buprenorphine, a partial mu-opioid agonist, reduces cortisol responses to stress. Here, the
investigators propose to further explore the role of the opioid system in mediating stress
responses in humans through the use of hydromorphone, a full mu opioid agonist, in addition
to acetaminophen. The investigators hypothesize that like acetaminophen, hydromorphone will
reduce both physiological and subjective measures of stress.
placebo, upon physiological, subjective, and hormonal responses to a stressful speech task
and a non-stressful control task in healthy adults. There is strong evidence in support of
the role of endogenous opioids and opiates in mediating social behavior in humans and other
animals, and particularly, in social distress. The investigators have recently shown that
buprenorphine, a partial mu-opioid agonist, reduces cortisol responses to stress. Here, the
investigators propose to further explore the role of the opioid system in mediating stress
responses in humans through the use of hydromorphone, a full mu opioid agonist, in addition
to acetaminophen. The investigators hypothesize that like acetaminophen, hydromorphone will
reduce both physiological and subjective measures of stress.
Participants be randomly assigned to receive 1000 mg acetaminophen, 2mg hydromorphone, 4mg
hydromorphone, or placebo at each of two sessions; one during which they well participate in
a stressful speaking task, and one during which they'll participate in a nonstressful control
task. Physiological and subjective measures will be taken throughout each session.
hydromorphone, or placebo at each of two sessions; one during which they well participate in
a stressful speaking task, and one during which they'll participate in a nonstressful control
task. Physiological and subjective measures will be taken throughout each session.
Inclusion Criteria:
- Healthy adult volunteers
Exclusion Criteria:
1. any current medical condition requiring medication or abnormal electrocardiogram
2. current or past medical condition considered to be a contraindication for the study
conditions
3. any current Axis I psychiatric disorder (APA, 1994) including Substance Use Disorder,
or Anxiety Disorder or Major Depression in the past year, any history of psychosis
4. less than high school education
5. lack of fluency in English
6. night shift work
7. Pregnancy, lactation or plans to become pregnant.
8. Use of hormonal contraception.
9. Daily cigarette smokers i.e., >7 cigarettes per week
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