Electronic Medical Record Review in Monitoring the Effects of Adherence on Myelosuppression and Morbidity in Patients With Newly Diagnosed Brain Tumors Receiving Temozolomide and Radiation Therapy

PRIMARY OBJECTIVES:

I. Retrospectively measure the frequency of nonadherence with established monitoring
guidelines in the target patient population.

II. Retrospectively assess the impact of nonadherence events on myelosuppression severity
and patient morbidity.

III. Prospectively measure the effect of an automated notification program on adherence
rates.

SECONDARY OBJECTIVES:

I. Quantify any time savings realized by patient care staff through the use of such a
program.

II. Quantify the number of patient care interventions that directly result from this
automated monitoring and notification program.

OUTLINE:

Patients' electronic medical records are reviewed for adherence, severe myelosuppression,
and patient morbidity retrospectively and prospectively.

Inclusion Criteria:

- RETROSPECTIVE: All patients seen in Dr. Lesser's clinic who received concurrent
temozolomide and radiation therapy followed by adjuvant temozolomide for newly
diagnosed malignant gliomas from 01/01/07 through 03/31/2010 will be analyzed

- PROSPECTIVE: All patients seen in Dr. Lesser's clinic who receive concurrent
temozolomide and radiation therapy followed by adjuvant temozolomide for newly
diagnosed malignant gliomas during and after the construction of the system until the
end of the study

Exclusion Criteria:

- Patients participating in clinical trials or other deviations from non-standard
therapies that engender similar monitoring risk will be evaluated for this study on a
case by case basis