Trial to Determine the Safety of Oral Ifetroban in Patients With a History of Aspirin Exacerbated Respiratory Disease

Inclusion Criteria:

1. Adults with a history of physician-diagnosed stable asthma (FEV1 of at least 1.25
liters and 60% or better than predicted* on two previous visits with no more than a
10% variation in those values, no increase in baseline dose of oral glucocorticoids
for asthma for at least three months, and no history of hospitalization or emergency
room visits for asthma for at least the prior six months).

2. Have a history of nasal polyposis.

3. Have a history of at least one clinical reaction to oral aspirin or other
nonselective cyclooxygenase (COX) inhibitor with features of lower (cough, chest
tightness, wheezing, dyspnea) and/or upper (rhinorrhea, sneezing, nasal obstruction,
conjunctival itching and discharge) airway involvement.

4. Currently receiving montelukast (at least 10 mg per day, oral) or Zafirlukast (at
least 20 mg twice per day, oral), with at least 1 week of therapy prior to first dose
of IMP.

Exclusion Criteria:

1. Be less than 18 years of age or greater than or equal to 65 years of age.

2. Be pregnant, nursing, or planning to become pregnant.

3. Be a current tobacco smoker (defined as a daily tobacco smoker during any of the six
months preceding this study or more than one instance of tobacco smoking in the last
three months).

4. Use of a beta blocker in the last week.

5. Use of an antihistamine in the 48 hours prior to the first dose of IMP.

6. Use of nasal decongestants in the 48 hours prior to the first dose of IMP.

7. Use of aspirin or non-steroidal inflammatory drug (NSAID) in the last two weeks.

8. Use of zileuton in the last two weeks.

9. Have required one or more doses of ≥ 40 mg prednisone or equivalent in the last two
weeks.

10. Have a history of systemic or life-threatening respiratory reaction to aspirin
requiring intubation or administration of epinephrine.

11. Have a history of peptic ulcer disease, gastrointestinal bleed, or current severe
gastro-esophageal reflux disease (GERD), defined as a patient currently requiring
more than two total doses of medication per day to treat persistent symptoms: either
more than two doses of any single medication type (antacid, proton pump inhibitor, or
H2 receptor antagonist), or more than 2 types of medication per day to treat
symptoms.

12. Have a history of tolerating a COX-1 blocking drug after their history of a
respiratory reaction to a similar drug.

13. Have a history of cardiovascular disease including myocardial infarction, heart
failure, atrial or ventricular rhythm disturbances, or angina, or a previous abnormal
electrocardiogram.

14. Have a history of bleeding diathesis or use of anticoagulant or antiplatelet drugs in
the last two weeks.

15. Have a history of allergy or hypersensitivity to ifetroban.

16. Have taken investigational drugs within 30 days before IMP administration.

17. Inability to understand the requirements of the study, inability to understand spoken
English and abide by the study restrictions and to return for the required treatments
and assessments.

18. Be otherwise unsuitable for the study, in the opinion of the investigator.