Safety Study of SGN-CD70A in Cancer Patients



Status:Completed
Conditions:Cancer, Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/21/2018
Start Date:August 2014
End Date:February 15, 2017

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 1 Trial of SGN-CD70A in Patients With CD70-Positive Malignancies

This study will examine the safety profile of SGN-CD70A. The study will test increasing doses
of SGN-CD70A given every 3 weeks (or an alternate dosing schedule up to every 6 weeks) to
small groups of patients. The goal is to find the highest dose of SGN-CD70A that can be given
to patients without causing unacceptable side effects. The pharmacokinetics and antitumor
activity of SGN-CD70A will also be evaluated.


Inclusion Criteria:

- Metastatic renal cell carcinoma, mantle cell lymphoma, or diffuse large B-cell
lymphoma including Grade 3b follicular lymphoma

- Relapsed, refractory, or progressive disease following at least 2 prior systemic
therapies

- Confirmed positive CD70 expression on tumor tissue

- Eastern Cooperative Oncology Group performance status 0 or 1

- Adequate baseline hematologic, pulmonary, renal, and hepatic function

- Measurable disease

Exclusion Criteria:

- Prior treatment with anti-CD70 directed therapy unless CD70 expression is confirmed on
tumor tissue obtained after the treatment

- Patients <100 days since prior allogeneic stem cell transplant

- Less than 4 weeks since prior treatment; or 2 weeks if patient experienced disease
progression on the prior treatment
We found this trial at
17
sites
Comprehensive Cancer Centers of Nevada
9280 W. Sunset Road Suite 100
Las Vegas, Nevada 89148
702.952.1251
Principal Investigator: Nicholas Vogelzang, MD
Phone: 281-863-4697
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
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Las Vegas, NV
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University of Alabama at Birmingham
1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
Principal Investigator: Andres Forero-Torres
Phone: 205-975-0960
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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Birmingham, AL
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James P. Wilmot Cancer Center at University of Rochester Medical Center
601 Elmwood Avenue
Rochester, New York 14642
(585) 275-5830
Principal Investigator: Paul Barr, MD
Phone: 585-275-4911
James P. Wilmot Cancer Center at University of Rochester Medical Center The Wilmot Cancer Center...
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Rochester, NY
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University of Texas Health Science Center at San Antonio
4502 Medical Drive
San Antonio, Texas 78284
(210) 567-7000
Principal Investigator: John Sarantopoulos, MD
Phone: 210-450-5962
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
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San Antonio, TX
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University of Michigan Comprehensive Cancer Center
1500 East Medical Center Drive
Ann Arbor, Michigan 48109
800-865-1125
Principal Investigator: David Smith, MD
Phone: 734-647-9437
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
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Ann Arbor, MI
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Texas Oncology - Austin Midtown
Austin, Texas 78705
Principal Investigator: Jason Melear, MD
Phone: 281-863-4697
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mi
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Austin, TX
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UNC Lineberger Comprehensive Cancer Center / University of North Carolina
Chapel Hill, North Carolina 27599
Principal Investigator: Steven Park, MD
Phone: 919-843-7046
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mi
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Chapel Hill, NC
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Medical University of South Carolina Hollings Cancer Center
Charleston, South Carolina 29425
Principal Investigator: Valeriy Sedov, MD
Phone: 843-792-1463
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Charleston, SC
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University of Cincinnati Cancer Institute
Cincinnati, Ohio 45267
Principal Investigator: John Morris, MD
Phone: 513-584-8500
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Cincinnati, OH
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Case Western Reserve University / University Hospitals Case Medical Center
Cleveland, Ohio 44106
Principal Investigator: Paolo Caimi, MD
Phone: 216-844-8573
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Cleveland, OH
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Karmanos Cancer Institute/Wayne State University
Detroit, Michigan
Principal Investigator: Elisabeth Heath, MD
Phone: 313-576-8495
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Detroit, MI
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City of Hope National Medical Center
1500 East Duarte Road
Duarte, California 91010
626-256-HOPE (4673)
Principal Investigator: Sumanta Kumar Pal, MD
Phone: 626-256-4673
City of Hope National Medical Center City of Hope is dedicated to making a difference...
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Duarte, CA
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Methodist Cancer Center
Houston, Texas 77030
Principal Investigator: Swaminathan Iyer, MD
Phone: 713-441-9984
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Houston, TX
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Cardinal Bernardin Cancer Center at Loyola University Medical Center
2160 S. First Ave.
Maywood, Illinois 60153
888-584-7888
Principal Investigator: Scott Smith, MD
Phone: 708-327-3228
Cardinal Bernardin Cancer Center at Loyola University Medical Center The Cardinal Bernardin Cancer Center is...
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Maywood, IL
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University of Pennsylvania - Perelman Center for Advanced Medicine
Philadelphia, Pennsylvania 19104
Principal Investigator: Jakub Svoboda, MD
Phone: 215-662-2062
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Philadelphia, PA
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Seattle Cancer Care Alliance / University of Washington
Seattle, Washington 98109
Principal Investigator: John Thompson, MD
Phone: 206-288-6448
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Seattle, WA
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Northwest Cancer Specialists
Vancouver, Washington 98684
Principal Investigator: Kathryn Kolibaba, MD
Phone: 281-863-4697
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Vancouver, WA
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