Use of Inhaled Nitric Oxide to Prevent Pulmonary Hypertension Associated to Stored Blood Transfusion



Status:Withdrawn
Conditions:High Blood Pressure (Hypertension), High Blood Pressure (Hypertension), Hematology
Therapuetic Areas:Cardiology / Vascular Diseases, Hematology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:March 2016
End Date:April 2017

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria

Pulmonary Hemodynamic Effects of Stored Red Blood Cell Transfusion in Post-Operative Cardiac Surgical Patients: Influence of Breathing Nitric Oxide. A Randomized Controlled Trial in the Cardiac-Intensive Care Unit.

The objective of this study is to assess if prolonged storage time of a packed red blood
cell unit may cause pulmonary vasoconstriction after transfusion, in a susceptible
population such as cardiac surgery patients. The investigators will also evaluate the
potential reversal effect of Inhaled Nitric Oxide on pulmonary vasoconstriction induced by
stored blood transfusions.

Patients will be randomized into one of the three groups:

I. Blood transfusion stored for less than 10 days II. Blood transfusion stored for more than
30 days III. Blood transfusion stored for more than 30 days days plus inhalation of Nitric
Oxide at 80 part per million for an hour during blood transfusion.

Inclusion Criteria:

1. Provide written informed consent

2. Elective cardiac or aortic surgery

3. One or more blood transfusions scheduled for clinical reasons

4. Presence of an arterial catheter and pulmonary arterial catheter

Exclusion Criteria:

1. Emergent cardiac surgery.

2. Patients requiring irradiated or washed blood transfusions.
We found this trial at
1
site
Massachusetts General Hospital
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
?
mi
from
Boston, MA
Click here to add this to my saved trials