Learning to BREATHE: A Randomized Controlled Trial to Lower Diabetes Risk in Adolescent Girls
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Depression, Depression, Obesity Weight Loss, Diabetes, Diabetes |
| Therapuetic Areas: | Endocrinology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 12 - 17 |
| Updated: | 4/21/2016 |
| Start Date: | January 2013 |
| End Date: | December 2016 |
Depression and Insulin Resistance in Adolescents
Type 2 diabetes is a chronic disease that puts people at risk for major health problems like
heart disease. Type 2 diabetes is the most common type of diabetes in adults. However, there
has been a concerning rise in type 2 diabetes among teenagers. Diabetes develops through
poor insulin sensitivity, meaning that insulin - an important chemical the body makes to
keep blood sugar normal - isn't working properly. Type 2 diabetes can be prevented by
improving insulin sensitivity. Stress is related to insulin sensitivity. Individuals who
feel stressed have worse insulin sensitivity than individuals who do not feel stressed. In
adults, decreasing stress leads to improvements in insulin sensitivity, but this hasn't been
tested in teenagers. The purpose of this study is to find out if taking part in a brief
group program to decrease stress will improve insulin sensitivity and lower diabetes risk in
teenage girls.
heart disease. Type 2 diabetes is the most common type of diabetes in adults. However, there
has been a concerning rise in type 2 diabetes among teenagers. Diabetes develops through
poor insulin sensitivity, meaning that insulin - an important chemical the body makes to
keep blood sugar normal - isn't working properly. Type 2 diabetes can be prevented by
improving insulin sensitivity. Stress is related to insulin sensitivity. Individuals who
feel stressed have worse insulin sensitivity than individuals who do not feel stressed. In
adults, decreasing stress leads to improvements in insulin sensitivity, but this hasn't been
tested in teenagers. The purpose of this study is to find out if taking part in a brief
group program to decrease stress will improve insulin sensitivity and lower diabetes risk in
teenage girls.
After a screening to determine eligibility, girls are randomly assigned to take part in one
of two 6-week group programs: 1) Learning to BREATHE - a mindfulness-based program, or 2)
Colorado Blues - a cognitive-behavioral program. After the group, girls return for three
follow-up visits over the course of a year. The main outcomes are depressive symptoms and
insulin resistance. We also are assessing stress, eating behavior, fitness, and mindfulness.
of two 6-week group programs: 1) Learning to BREATHE - a mindfulness-based program, or 2)
Colorado Blues - a cognitive-behavioral program. After the group, girls return for three
follow-up visits over the course of a year. The main outcomes are depressive symptoms and
insulin resistance. We also are assessing stress, eating behavior, fitness, and mindfulness.
Inclusion Criteria:
- Age 12-17 years
- Female
- Overweight or obese, defined as a body mass index (BMI; kg/m2) ≥ 85th percentile for
age
- Family history of type 2 diabetes or pre-diabetes in 1st degree relative (e.g.,
parent or sibling) or 2nd degree relative (e.g., aunt, uncle, or grandparent)
- Elevated stress/symptoms of depression as indicated by a Center for Epidemiological
Studies-Depression Scale Total Score ≥ 16
- Good general health as reported by adolescent and parent/guardian
- English speaking (required for adolescent only, because the groups will be conducted
in English)
Exclusion Criteria:
- Pregnancy
- Current psychiatric disorder such as major depressive disorder necessitating
treatment
- Type 2 diabetes as indicated by fasting glucose > 126 mg/dL
- Use of medication affecting insulin resistance, body weight, or mood such as
anti-depressants or stimulants
- Current psychotherapy or weight loss treatment
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