Vitamin D and Muscle Metabolic Function
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 60 - Any |
| Updated: | 4/17/2018 |
| Start Date: | September 2014 |
| End Date: | March 1, 2018 |
Vitamin D Contribution to Muscle Metabolic Function in Aged Adults
The purpose of this study is to identify the magnitude of muscle lipid redistribution and
muscle oxygen use in individuals 60 years old or older following combined treatment of
vitamin D repletion and aerobic training compared to vitamin D repletion alone, aerobic
training alone, or no treatment.
muscle oxygen use in individuals 60 years old or older following combined treatment of
vitamin D repletion and aerobic training compared to vitamin D repletion alone, aerobic
training alone, or no treatment.
The investigators plan to recruit approximately 56 aged individuals with vitamin D
insufficiency for a 13 week trial. All subjects will be 60 years of age or older.
Participants will be randomized to one of four groups: vitamin D (50,000IU/wk) + aerobic
training (7 days during the 13th week); vitamin D (50,000IU/wk) + normal daily activity
during the 13th week; placebo + aerobic training (7 days during the 13th week); or placebo +
normal daily activity during the 13th week.
Following screening and informed consent process a physical activity questionnaire will be
administered. A blood draw will then be conducted at baseline, midpoint and endpoint.
Collected blood for the purposes of this study will assess vitamin D status (25(OH)D),
parathyroid hormone, ionized calcium, insulin, and a comprehensive metabolic panel. At
baseline and endpoint muscle lipid will be assessed using Magnetic Resonance Spectroscopy and
muscle oxygen consumption will be determined using a novel hybrid diffuse optical instrument
consisting of a near-infrared spectroscopy and a diffuse correlation spectroscopy. In
addition, at each study time point 3 dietary recalls will be completed and physical activity
will be measured using an accelerometer.
insufficiency for a 13 week trial. All subjects will be 60 years of age or older.
Participants will be randomized to one of four groups: vitamin D (50,000IU/wk) + aerobic
training (7 days during the 13th week); vitamin D (50,000IU/wk) + normal daily activity
during the 13th week; placebo + aerobic training (7 days during the 13th week); or placebo +
normal daily activity during the 13th week.
Following screening and informed consent process a physical activity questionnaire will be
administered. A blood draw will then be conducted at baseline, midpoint and endpoint.
Collected blood for the purposes of this study will assess vitamin D status (25(OH)D),
parathyroid hormone, ionized calcium, insulin, and a comprehensive metabolic panel. At
baseline and endpoint muscle lipid will be assessed using Magnetic Resonance Spectroscopy and
muscle oxygen consumption will be determined using a novel hybrid diffuse optical instrument
consisting of a near-infrared spectroscopy and a diffuse correlation spectroscopy. In
addition, at each study time point 3 dietary recalls will be completed and physical activity
will be measured using an accelerometer.
Inclusion Criteria:
- Age: 60 and older
- BMI: 18.5-29
- Communicates fluently in English
Exclusion Criteria:
- Metal implant not suitable for MRI
- Any form of hormone replacement therapy
- Engage in more than 1 hr/week of vigorous activity
- Participated in a high-intensity resistance or aerobic training program in the last 3
months
- Lower extremity injury or surgery in the past 3 months
- Foot sores or bone conditions severely limiting ability to move or perform exercise or
joint pain made worse by mild exercise
- Diabetes, inflammatory bowel disease, renal disease or uncontrolled hypertension.
- Currently have or had a history of cardiovascular or pulmonary disease that would
preclude the involvement in the performance of exercise
- History of myopathy (including congenital myopathies)
- History of neurological conditions related to spinal derangement, disk disease,
peripheral neuropathies, tremor and rigidity
- Past medical history of hyperparathyroidism, kidney stones or rhabdomyolysis
- Currently receiving treatment for vitamin D deficiency
- Vitamin D level >30ng/mL
- Currently smoking
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