Bone Mass and Strength After Kidney Transplantation



Status:Active, not recruiting
Conditions:Renal Impairment / Chronic Kidney Disease, Renal Impairment / Chronic Kidney Disease, Orthopedic
Therapuetic Areas:Nephrology / Urology, Orthopedics / Podiatry
Healthy:No
Age Range:18 - Any
Updated:2/1/2019
Start Date:August 18, 2014
End Date:December 2020

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Trial Summary
Trial Overview
Inclusion Criteria

A Comparative Trial of Calcitriol Versus Placebo for the Preservation of Bone Mass and Strength After Kidney Transplantation

The purpose of this study is to test whether active vitamin D (calcitriol) protects bones
from weakening and protects blood vessels from calcium deposits over the first year of kidney
transplantation.

Kidney transplant recipients at highest fracture risk, as determined by epidemiologic studies
(Caucasians and older recipients). Rocaltrol (calcitriol) is a synthetic vitamin D analog
which is active in the regulation of the absorption of calcium from the gastrointestinal
tract and its utilization in the body.

Inclusion Criteria:

- Age older than 18

- Self-describes as White race

Exclusion Criteria:

- Lower extremity amputations

- Non-ambulatory

- Paget´s disease of bone

- Current hyperthyroidism, untreated hypothyroidism

- Medical diseases (end stage liver, intestinal malabsorption)

- Use within the prior year pod anti-seizure medications that induce the cytochrome P450
system, testosterone, estrogen, selective estrogen receptor modulators

- Weight >300 pounds

- Dual organ transplant

- Myocardial infarction or stroke

- Tobacco use within the past year
We found this trial at
1
site
Columbia University Medical Center
630 W 168th St
New York, New York
212-305-2862
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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mi
from
New York, NY
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