Smartphone-Delivered Attentional Bias Modification Training in Helping Patients Quit Smoking

PRIMARY OBJECTIVES:

I. To determine the feasibility of smartphone-delivered, in-home attentional bias
modification (ABM) to reduce attentional bias (AB) to smoking cues and to reduce smoking
behavior in the short- and long-term.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM I: Patients receive ABM training over 30 minutes through a smartphone on days 1-14.
Patients then receive nicotine patches for up to 8 weeks.

ARM II: Patients undergo sham training on days 1-14. Patients then receive nicotine patches
for up to 8 weeks.

After completion of study treatment, patients are followed up on days 15, 29, 43, 57, and 72.

Inclusion Criteria:

- Smoke an average of 5 or more cigarettes or little cigars per day (CPD) prior to
telephone screen

- Produce an expired carbon monoxide (CO) level greater than or equal to 6 parts per
million (ppm) or a NicAlert reading of > 2

- Have a working telephone

- Interested in quitting smoking in the next 30 days

- Fluency in spoken and written English

- Must sign the picture consent form

Exclusion Criteria:

- Taking psychotropic, anticonvulsive, or narcotic medication

- Meet criteria for a current major depressive episode or suicidality

- Have a history of neurological illness or closed head injury

- Report uncorrected vision problems

- Involved in current smoking cessation activity

- Testing positive on a urine drug screen for drugs of abuse/potential abuse

- Women who are pregnant or breastfeeding

- Considered by the investigator to be an unsuitable or unstable candidate (e.g., due to
cognitive impairment)

- Shares the same address as a currently enrolled participant

- Unwilling to alter or remove hairstyle, hair extensions, or wig during the clinic
visits to allow for correct electroencephalography (EEG) sensor placement

- Reports diagnosis of seizure disorder

- Unwilling to use nicotine replacement therapy (NRT) patches