The Focal Electro-Oculogram in Macular Disease
| Status: | Recruiting |
|---|---|
| Conditions: | Ocular |
| Therapuetic Areas: | Ophthalmology |
| Healthy: | No |
| Age Range: | 10 - Any |
| Updated: | 1/30/2019 |
| Start Date: | August 23, 2014 |
| End Date: | December 31, 2019 |
| Contact: | Daniel W Claus, R.N. |
| Email: | daniel.claus@nih.gov |
| Phone: | (301) 496-9058 |
Background:
- Maculopathies are eye conditions that affect the center of the retina. Retina health
depends on the RPE, a layer behind the retina. A new test may measure the health of the
central retina and RPE.
Objective:
- To use the focal electro-oculogram test to understand how the central retina and RPE are
affected in maculopathies.
Eligibility:
- People at least 10 years old with a maculopathy.
- Healthy volunteers.
Design:
- Participants will be screened with medical and eye history and an eye exam. Pictures
will be taken of the eyes.
- Their eyes may be dilated.
- They may have a field test. They will look into a lens and press a button when they see
a light. First, they may sit in the dark for 40 minutes.
- Participants will have 1 7 visits over 18 months.
- Their vision will be tested and eye pressure measured.
- Their pupils will be dilated with eye drops and researchers may take pictures of the
retina and the inside of the eye, and measure the thickness of the retina.
- Participants will have an electro-oculogram. They will look at a 2 LED lights and follow
them back and forth for 10 seconds once per minute. Participants will be in darkness for
15 minutes and in light for 20 minutes. One skin electrode will be placed on the nose
and one next to the eye.
- Participants with maculopathy will also have:
- Field test.
- Electroretinogram. Participants will get numbing eye drops and special contact lenses. A
small metal electrode will be taped to the forehead. Participants will watch flashing
lights and try not to blink. First, they may sit in the dark for 40 minutes.
- Maculopathies are eye conditions that affect the center of the retina. Retina health
depends on the RPE, a layer behind the retina. A new test may measure the health of the
central retina and RPE.
Objective:
- To use the focal electro-oculogram test to understand how the central retina and RPE are
affected in maculopathies.
Eligibility:
- People at least 10 years old with a maculopathy.
- Healthy volunteers.
Design:
- Participants will be screened with medical and eye history and an eye exam. Pictures
will be taken of the eyes.
- Their eyes may be dilated.
- They may have a field test. They will look into a lens and press a button when they see
a light. First, they may sit in the dark for 40 minutes.
- Participants will have 1 7 visits over 18 months.
- Their vision will be tested and eye pressure measured.
- Their pupils will be dilated with eye drops and researchers may take pictures of the
retina and the inside of the eye, and measure the thickness of the retina.
- Participants will have an electro-oculogram. They will look at a 2 LED lights and follow
them back and forth for 10 seconds once per minute. Participants will be in darkness for
15 minutes and in light for 20 minutes. One skin electrode will be placed on the nose
and one next to the eye.
- Participants with maculopathy will also have:
- Field test.
- Electroretinogram. Participants will get numbing eye drops and special contact lenses. A
small metal electrode will be taped to the forehead. Participants will watch flashing
lights and try not to blink. First, they may sit in the dark for 40 minutes.
OBJECTIVE:
The objective of this protocol is to investigate the local response of the retinal pigment
epithelium (RPE) across the posterior pole of the eye by recording the focal electrooculogram
(EOG) in participants with macular disease.
STUDY POPULATION:
Up to 50 healthy volunteers and 80 participants, age 10 or older, with macular disorders
affecting the retina/retinal pigment epithelium complex. Examples of such macular disorders
include Stargardt s disease and age-related macular degeneration (AMD).
DESIGN:
This single-center, observational, case-control study will be comprised of three related
aims. The first aim is focused on developing the focal EOG method which will require
parameter optimization. The second aim is focused on establishing the normal range and
variability of the focal EOG in normal volunteers. The third aim is to examine the focal EOG
in participants with macular disease.
OUTCOME MEASURES:
The primary outcome for this study is to develop a method for recording the focal EOG. The
secondary outcome will be to establish the normal range for the focal EOG and determine the
inter-session and intra-session variabilities of this test. Exploratory outcomes include: 1)
to examine the focal EOG in participants with macular diseases and 2) determine the
inter-session and intra-session variabilities of this test in participants with macular
diseases.
The objective of this protocol is to investigate the local response of the retinal pigment
epithelium (RPE) across the posterior pole of the eye by recording the focal electrooculogram
(EOG) in participants with macular disease.
STUDY POPULATION:
Up to 50 healthy volunteers and 80 participants, age 10 or older, with macular disorders
affecting the retina/retinal pigment epithelium complex. Examples of such macular disorders
include Stargardt s disease and age-related macular degeneration (AMD).
DESIGN:
This single-center, observational, case-control study will be comprised of three related
aims. The first aim is focused on developing the focal EOG method which will require
parameter optimization. The second aim is focused on establishing the normal range and
variability of the focal EOG in normal volunteers. The third aim is to examine the focal EOG
in participants with macular disease.
OUTCOME MEASURES:
The primary outcome for this study is to develop a method for recording the focal EOG. The
secondary outcome will be to establish the normal range for the focal EOG and determine the
inter-session and intra-session variabilities of this test. Exploratory outcomes include: 1)
to examine the focal EOG in participants with macular diseases and 2) determine the
inter-session and intra-session variabilities of this test in participants with macular
diseases.
- INCLUSION CRITERIA:
1. Participant must be 10 years of age or older.
2. Participant (or legal guardian) must understand and sign the protocol s informed
consent document.
3. Participant must be able to cooperate with the testing required for this study.
4. For Participants with macular disease only:
1. Participant must have macular disease, defined as evidence of loss of
centrally mediated retinal dysfunction and/or degeneration as established by
standard clinical methods including perimetry, ERG and imaging.
2. Participant must have a measurable visual acuity.
5. For Healthy Volunteers only:
1. Participant must have visual acuity of 20/20 or better in at least one eye.
EXCLUSION CRITERIA:
1) Participant with pre-retinal media opacities that would prevent focal light
presentation.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
Phone: 800-411-1222
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