Minimally Invasive Biomarker for Asthma Disease Severity
| Status: | Completed |
|---|---|
| Conditions: | Asthma, Healthy Studies |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/8/2015 |
| Start Date: | July 2014 |
| End Date: | December 2014 |
| Contact: | Matthew A Rank, MD |
| Email: | Rank.Matthew@mayo.edu |
| Phone: | 480-301-4284 |
Feasibility of Using an Eosinophil-Specific Biomarker-(Eosinophil Peroxidase) in Clinical Practice
Can a clinical test be developed that could help manage asthma symptoms?
Project goals:
Develop a point-of-service assay to assess eosinophilic airway inflammation
Proposal Specific Aims:
1. To establish the infrastructure and test the feasibility of sputum collection in a
clinical setting as a minimally invasive patient sampling process for biomarker testing
2. To transform the laboratory-based eosinophil peroxidase (EPX) ELISA detection assay
into a clinic-friendly assessment that does not require sophisticated laboratory
equipment
Develop a point-of-service assay to assess eosinophilic airway inflammation
Proposal Specific Aims:
1. To establish the infrastructure and test the feasibility of sputum collection in a
clinical setting as a minimally invasive patient sampling process for biomarker testing
2. To transform the laboratory-based eosinophil peroxidase (EPX) ELISA detection assay
into a clinic-friendly assessment that does not require sophisticated laboratory
equipment
Asthma subjects:
Inclusion
- Provider diagnosed asthma
- FeNO>50 ppb
- FEV1 > 1.0 Liter
Exclusion
- COPD by history
- Bronchiectasis by history
- Pregnant participants
Normal subjects:
Inclusion
- Age matched to asthma subjects
Exclusion
- Any eosinophil disorder by history
- Asthma by history
- Rhinitis or sinusitis by history
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