Ledipasvir/Sofosbuvir Fixed-Dose Combination and Vedroprevir With or Without Ribavirin in Treatment-Experienced Participants With Chronic Genotype 1 HCV Infection and Cirrhosis

Inclusion Criteria:

- Age ≥ 18 years, with chronic HCV genotype 1 infection

- Documentation as treatment-experienced having received pegylated interferon (Peg-IFN)
+ RBV ≥ 4 weeks of duration without an additional agent in the regimen without
achieving sustained viral response (SVR)

- Presence of compensated cirrhosis

- Screening laboratory values within defined thresholds

- Must use specific contraceptive methods if female of childbearing potential or
sexually active male

- Not pregnant or a nursing female

Exclusion Criteria:

- Co-infection with HIV or hepatitis B virus (HBV)

- Current or prior history of clinical hepatic decompensation

- Chronic use of systemic immunosuppressive agents

- History of clinically significant illness or any other medical disorder that may
interfere with subject treatment, assessment or compliance with the protocol