A Study of Evacetrapib (LY2484595) in Participants With High Cholesterol



Status:Terminated
Conditions:High Cholesterol
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:4/17/2018
Start Date:October 2014
End Date:December 2015

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Trial Summary
Trial Overview
Inclusion Criteria

The Addition of Evacetrapib to Atorvastatin Compared to Placebo, High Intensity Atorvastatin, and Atorvastatin With Ezetimibe to Evaluate LDL-C Lowering in Patients With Primary Hyperlipidemia - The ACCENTUATE Study

The purpose of the ACCENTUATE study is to evaluate whether the study drug known as
evacetrapib is effective in treating participants with high cholesterol and atherosclerotic
cardiovascular disease (ASCVD) and/or diabetes.


Inclusion Criteria:

- Must be treated with atorvastatin 40 mg/day for at least 30 days prior to screening

- Have an LDL-C >70 mg/deciliter(dL) or non-HDL-C >100 mg/dL

- Have screening triglycerides ≤400 mg/dL (≤4.5 millimoles/Liter)

- Individuals with ASCVD and/or individuals with type 1 or type 2 diabetes

Exclusion Criteria:

- Have a hemoglobin A1c (HbA1c) >9.5%

- New York Heart Association (NYHA) class III or IV congestive heart failure

- History of either a transient ischemic stroke or ischemic stroke <30 days

- History of acute coronary syndrome (ACS) <30 days
We found this trial at
62
sites
Holston Medical Group Clinical Research
Kingsport, Tennessee 37660
237
mi
from 43215
Kingsport, TN
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Avail Clinical Research
860 Peachwood Drive
DeLand, Florida 32720
(386) 740-0770
Site Overview Avail Clinical Research is a renowned and experienced clinical research site conducting Phase...
760
mi
from 43215
DeLand, FL
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Suncoast Research Group, LLC
2128 W Flagler St # 201
Miami, Florida 33144
993
mi
from 43215
Miami, FL
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Northwest Heart Clinical Research
Arlington Heights, Illinois 60005
296
mi
from 43215
Arlington Heights, IL
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Asheville Cardiology Associates
Asheville, North Carolina 28802
300
mi
from 43215
Asheville, NC
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University of Colorado Health Sciences Ctr.
Aurora, Colorado 80045
1154
mi
from 43215
Aurora, CO
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Maryland Cardiovascular Specialists
Baltimore, Maryland 21229
340
mi
from 43215
Baltimore, MD
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Overlea Personal Physicians
Baltimore, Maryland 21236
344
mi
from 43215
Baltimore, MD
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Northwest Clinical Research Center
Bellevue, Washington 98007
1998
mi
from 43215
Bellevue, WA
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Grace Research, LLC
Bossier City, Louisiana 71111
786
mi
from 43215
Bossier City, LA
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Zasa Clinical Research
Boynton Beach, Florida 33437
943
mi
from 43215
Boynton Beach, FL
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Advanced Clinical Research
Carmichael, California 95608
2034
mi
from 43215
Carmichael, CA
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Metrolina Internal Medicine
Charlotte, North Carolina 28204
348
mi
from 43215
Charlotte, NC
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Cedar-Crosse Research Center
Chicago, Illinois 60607
275
mi
from 43215
Chicago, IL
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Cardiac Research
Colorado Springs, Colorado 80909
1161
mi
from 43215
Colorado Springs, CO
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Aventiv Research
Columbus, Ohio 43213
8
mi
from 43215
Columbus, OH
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Georgia Heart Specialists
Covington, Georgia 30014
442
mi
from 43215
Covington, GA
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Midwest CRC
Crystal Lake, Illinois 60012
318
mi
from 43215
Crystal Lake, IL
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Partners in Clinical Research, LLC
Cumberland, Rhode Island 02864
621
mi
from 43215
Cumberland, RI
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Cardiology Research Assoc.
Daytona Beach, Florida 32117
751
mi
from 43215
Daytona Beach, FL
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Tooraj Joseph Raoof M.D., Inc.
Encino, California 91436
1982
mi
from 43215
Encino, CA
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Lillestol Research LLC
Fargo, North Dakota 58103
838
mi
from 43215
Fargo, ND
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Alan Graff, MD, PA
Fort Lauderdale, Florida 33308
966
mi
from 43215
Fort Lauderdale, FL
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United Osteoporosis Center
Gainesville, Georgia 30501
392
mi
from 43215
Gainesville, GA
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High Point Clinical Trials Center
High Point, North Carolina 27265
322
mi
from 43215
High Point, NC
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East West Medical Institute
Honolulu, Hawaii 96814
4501
mi
from 43215
Honolulu, HI
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Heart Center Research, Llc
Huntsville, Alabama 35801
410
mi
from 43215
Huntsville, AL
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Hutchinson Clinic
Hutchinson, Kansas 67502
809
mi
from 43215
Hutchinson, KS
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Cape Cod Research Institute
Hyannis, Massachusetts 02601
675
mi
from 43215
Hyannis, MA
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Indiana Heart Physicians
Indianapolis, Indiana 46237
163
mi
from 43215
Indianapolis, IN
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Midwest Institute for Clinical Research
Indianapolis, Indiana 46260
167
mi
from 43215
Indianapolis, IN
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Nature Coast Clinical Research
Inverness, Florida 34452
772
mi
from 43215
Inverness, FL
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Irvine Clinical Research Center
Irvine, California 92618
1956
mi
from 43215
Irvine, CA
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Clinical Investigation Specialists
Kenosha, Wisconsin 53142
309
mi
from 43215
Kenosha, WI
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Palm Research Center
Las Vegas, Nevada 89102
1756
mi
from 43215
Las Vegas, NV
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VA Long Beach Healthcare System
Long Beach, California 90822
1972
mi
from 43215
Long Beach, CA
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Community Medical Associates Inc
Louisville, Kentucky 40207
183
mi
from 43215
Louisville, KY
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Solaris Clinical Research
Meridian, Idaho 83646
1727
mi
from 43215
Meridian, ID
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Desert Clinical Research
Mesa, Arizona 85201
1651
mi
from 43215
Mesa, AZ
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ActivMed Practices & Research
Methuen, Massachusetts 01844
642
mi
from 43215
Methuen, MA
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PMG Research of Charleston, LLC
Mount Pleasant, South Carolina 29464
524
mi
from 43215
Mount Pleasant, SC
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Medex Healthcare Research, Inc.
New York, New York 10004
475
mi
from 43215
New York, NY
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South Oklahoma Heart Research
Oklahoma City, Oklahoma 73135
847
mi
from 43215
Oklahoma City, OK
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Central Phoenix Medical Clinic
Phoenix, Arizona 85020
1662
mi
from 43215
Phoenix, AZ
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Research and Cardiovascular Corp.
Ponce, 00717
1806
mi
from 43215
Ponce,
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Progressive Medical Research
Port Orange, Florida 32127
758
mi
from 43215
Port Orange, FL
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Portland Preventive Cardiology, LLC
Portland, Oregon 97225
2031
mi
from 43215
Portland, OR
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Rancho Cucamonga Clinical
Rancho Cucamonga, California 91730
1936
mi
from 43215
Rancho Cucamonga, CA
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Black Hills Cardiovascular Research Group
Rapid City, South Dakota 57701
1072
mi
from 43215
Rapid City, SD
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National Clinical Research - Richmond, Inc.
Richmond, Virginia 23294
335
mi
from 43215
Richmond, VA
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Boice-Willis Clinic
Rocky Mount, North Carolina 27804
395
mi
from 43215
Rocky Mount, NC
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Medex Healthcare Research, Inc.
Saint Louis, Missouri 63117
401
mi
from 43215
Saint Louis, MO
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Saratoga Clinical Research LLC
Saratoga Springs, New York 12866
523
mi
from 43215
Saratoga Springs, NY
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Heart and Vascular Center of New Brunswick LLC
Somerset, New Jersey 08873
432
mi
from 43215
Somerset, NJ
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Kootenai Heart Clinics
Spokane, Washington 99204
1778
mi
from 43215
Spokane, WA
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Encompass Clinical Research
Spring Valley, California 91978
1942
mi
from 43215
Spring Valley, CA
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Northwest Houston Heart Center
Tomball, Texas 77375
984
mi
from 43215
Tomball, TX
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University Clinical Investigators
Tustin, California 92780
1958
mi
from 43215
Tustin, CA
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Diablo Clinical Research Inc
Walnut creek, California 94598
2083
mi
from 43215
Walnut creek, CA
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Cardiology Partners Clinical Research Institute
Wellington, Florida 33449
933
mi
from 43215
Wellington, FL
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Buffalo Cardiology & Pulmonary Associates
Williamsville, New York 14221
304
mi
from 43215
Williamsville, NY
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PMG Research of Wilmington
1907 Tradd Ct
Wilmington, North Carolina 28401
(910) 799-5500
PMG Research of Wilmington PMG Research of Wilmington has two offices situated in a 1...
484
mi
from 43215
Wilmington, NC
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