A Study of Evacetrapib (LY2484595) in Participants With High Cholesterol



Status:Terminated
Conditions:High Cholesterol
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:4/17/2018
Start Date:October 2014
End Date:December 2015

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Trial Summary
Trial Overview
Inclusion Criteria

The Addition of Evacetrapib to Atorvastatin Compared to Placebo, High Intensity Atorvastatin, and Atorvastatin With Ezetimibe to Evaluate LDL-C Lowering in Patients With Primary Hyperlipidemia - The ACCENTUATE Study

The purpose of the ACCENTUATE study is to evaluate whether the study drug known as
evacetrapib is effective in treating participants with high cholesterol and atherosclerotic
cardiovascular disease (ASCVD) and/or diabetes.


Inclusion Criteria:

- Must be treated with atorvastatin 40 mg/day for at least 30 days prior to screening

- Have an LDL-C >70 mg/deciliter(dL) or non-HDL-C >100 mg/dL

- Have screening triglycerides ≤400 mg/dL (≤4.5 millimoles/Liter)

- Individuals with ASCVD and/or individuals with type 1 or type 2 diabetes

Exclusion Criteria:

- Have a hemoglobin A1c (HbA1c) >9.5%

- New York Heart Association (NYHA) class III or IV congestive heart failure

- History of either a transient ischemic stroke or ischemic stroke <30 days

- History of acute coronary syndrome (ACS) <30 days
We found this trial at
62
sites
Indiana Heart Physicians
Indianapolis, Indiana 46237
646
mi
from
Indianapolis, IN
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Avail Clinical Research
860 Peachwood Drive
DeLand, Florida 32720
(386) 740-0770
Site Overview Avail Clinical Research is a renowned and experienced clinical research site conducting Phase...
1123
mi
from
DeLand, FL
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Suncoast Research Group, LLC
2128 W Flagler St # 201
Miami, Florida 33144
1319
mi
from
Miami, FL
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Northwest Heart Clinical Research
Arlington Heights, Illinois 60005
599
mi
from
Arlington Heights, IL
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Asheville Cardiology Associates
Asheville, North Carolina 28802
851
mi
from
Asheville, NC
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University of Colorado Health Sciences Ctr.
Aurora, Colorado 80045
402
mi
from
Aurora, CO
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Maryland Cardiovascular Specialists
Baltimore, Maryland 21229
1144
mi
from
Baltimore, MD
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Overlea Personal Physicians
Baltimore, Maryland 21236
1148
mi
from
Baltimore, MD
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Northwest Clinical Research Center
Bellevue, Washington 98007
1402
mi
from
Bellevue, WA
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Grace Research, LLC
Bossier City, Louisiana 71111
429
mi
from
Bossier City, LA
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Zasa Clinical Research
Boynton Beach, Florida 33437
1288
mi
from
Boynton Beach, FL
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Advanced Clinical Research
Carmichael, California 95608
1274
mi
from
Carmichael, CA
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Metrolina Internal Medicine
Charlotte, North Carolina 28204
958
mi
from
Charlotte, NC
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Cedar-Crosse Research Center
Chicago, Illinois 60607
609
mi
from
Chicago, IL
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Cardiac Research
Colorado Springs, Colorado 80909
384
mi
from
Colorado Springs, CO
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Aventiv Research
Columbus, Ohio 43213
817
mi
from
Columbus, OH
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Georgia Heart Specialists
Covington, Georgia 30014
833
mi
from
Covington, GA
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Midwest CRC
Crystal Lake, Illinois 60012
591
mi
from
Crystal Lake, IL
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Partners in Clinical Research, LLC
Cumberland, Rhode Island 02864
1424
mi
from
Cumberland, RI
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Cardiology Research Assoc.
Daytona Beach, Florida 32117
1131
mi
from
Daytona Beach, FL
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Tooraj Joseph Raoof M.D., Inc.
Encino, California 91436
1179
mi
from
Encino, CA
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Lillestol Research LLC
Fargo, North Dakota 58103
631
mi
from
Fargo, ND
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Alan Graff, MD, PA
Fort Lauderdale, Florida 33308
1306
mi
from
Fort Lauderdale, FL
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United Osteoporosis Center
Gainesville, Georgia 30501
816
mi
from
Gainesville, GA
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High Point Clinical Trials Center
High Point, North Carolina 27265
991
mi
from
High Point, NC
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East West Medical Institute
Honolulu, Hawaii 96814
3717
mi
from
Honolulu, HI
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Heart Center Research, Llc
Huntsville, Alabama 35801
660
mi
from
Huntsville, AL
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Hutchinson Clinic
Hutchinson, Kansas 67502
24
mi
from
Hutchinson, KS
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Cape Cod Research Institute
Hyannis, Massachusetts 02601
1482
mi
from
Hyannis, MA
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Midwest Institute for Clinical Research
Indianapolis, Indiana 46260
643
mi
from
Indianapolis, IN
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Nature Coast Clinical Research
Inverness, Florida 34452
1084
mi
from
Inverness, FL
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Irvine Clinical Research Center
Irvine, California 92618
1150
mi
from
Irvine, CA
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Clinical Investigation Specialists
Kenosha, Wisconsin 53142
620
mi
from
Kenosha, WI
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Holston Medical Group Clinical Research
Kingsport, Tennessee 37660
843
mi
from
Kingsport, TN
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Palm Research Center
Las Vegas, Nevada 89102
960
mi
from
Las Vegas, NV
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VA Long Beach Healthcare System
Long Beach, California 90822
1167
mi
from
Long Beach, CA
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Community Medical Associates Inc
Louisville, Kentucky 40207
663
mi
from
Louisville, KY
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Solaris Clinical Research
Meridian, Idaho 83646
1053
mi
from
Meridian, ID
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Desert Clinical Research
Mesa, Arizona 85201
841
mi
from
Mesa, AZ
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ActivMed Practices & Research
Methuen, Massachusetts 01844
1439
mi
from
Methuen, MA
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PMG Research of Charleston, LLC
Mount Pleasant, South Carolina 29464
1065
mi
from
Mount Pleasant, SC
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Medex Healthcare Research, Inc.
New York, New York 10004
1284
mi
from
New York, NY
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South Oklahoma Heart Research
Oklahoma City, Oklahoma 73135
163
mi
from
Oklahoma City, OK
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Central Phoenix Medical Clinic
Phoenix, Arizona 85020
853
mi
from
Phoenix, AZ
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Research and Cardiovascular Corp.
Ponce, 00717
2325
mi
from
Ponce,
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Progressive Medical Research
Port Orange, Florida 32127
1136
mi
from
Port Orange, FL
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Portland Preventive Cardiology, LLC
Portland, Oregon 97225
1388
mi
from
Portland, OR
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Rancho Cucamonga Clinical
Rancho Cucamonga, California 91730
1132
mi
from
Rancho Cucamonga, CA
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Black Hills Cardiovascular Research Group
Rapid City, South Dakota 57701
520
mi
from
Rapid City, SD
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National Clinical Research - Richmond, Inc.
Richmond, Virginia 23294
1106
mi
from
Richmond, VA
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Boice-Willis Clinic
Rocky Mount, North Carolina 27804
1109
mi
from
Rocky Mount, NC
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Medex Healthcare Research, Inc.
Saint Louis, Missouri 63117
411
mi
from
Saint Louis, MO
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Saratoga Clinical Research LLC
Saratoga Springs, New York 12866
1311
mi
from
Saratoga Springs, NY
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Heart and Vascular Center of New Brunswick LLC
Somerset, New Jersey 08873
1241
mi
from
Somerset, NJ
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Kootenai Heart Clinics
Spokane, Washington 99204
1201
mi
from
Spokane, WA
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Encompass Clinical Research
Spring Valley, California 91978
1133
mi
from
Spring Valley, CA
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Northwest Houston Heart Center
Tomball, Texas 77375
543
mi
from
Tomball, TX
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University Clinical Investigators
Tustin, California 92780
1152
mi
from
Tustin, CA
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Diablo Clinical Research Inc
Walnut creek, California 94598
1317
mi
from
Walnut creek, CA
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Cardiology Partners Clinical Research Institute
Wellington, Florida 33449
1277
mi
from
Wellington, FL
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Buffalo Cardiology & Pulmonary Associates
Williamsville, New York 14221
1064
mi
from
Williamsville, NY
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PMG Research of Wilmington
1907 Tradd Ct
Wilmington, North Carolina 28401
(910) 799-5500
PMG Research of Wilmington PMG Research of Wilmington has two offices situated in a 1...
1135
mi
from
Wilmington, NC
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