A Study of Evacetrapib (LY2484595) in Participants With High Cholesterol



Status:Terminated
Conditions:High Cholesterol
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:4/17/2018
Start Date:October 2014
End Date:December 2015

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Trial Summary
Trial Overview
Inclusion Criteria

The Addition of Evacetrapib to Atorvastatin Compared to Placebo, High Intensity Atorvastatin, and Atorvastatin With Ezetimibe to Evaluate LDL-C Lowering in Patients With Primary Hyperlipidemia - The ACCENTUATE Study

The purpose of the ACCENTUATE study is to evaluate whether the study drug known as
evacetrapib is effective in treating participants with high cholesterol and atherosclerotic
cardiovascular disease (ASCVD) and/or diabetes.


Inclusion Criteria:

- Must be treated with atorvastatin 40 mg/day for at least 30 days prior to screening

- Have an LDL-C >70 mg/deciliter(dL) or non-HDL-C >100 mg/dL

- Have screening triglycerides ≤400 mg/dL (≤4.5 millimoles/Liter)

- Individuals with ASCVD and/or individuals with type 1 or type 2 diabetes

Exclusion Criteria:

- Have a hemoglobin A1c (HbA1c) >9.5%

- New York Heart Association (NYHA) class III or IV congestive heart failure

- History of either a transient ischemic stroke or ischemic stroke <30 days

- History of acute coronary syndrome (ACS) <30 days
We found this trial at
62
sites
PMG Research of Wilmington
1907 Tradd Ct
Wilmington, North Carolina 28401
(910) 799-5500
PMG Research of Wilmington PMG Research of Wilmington has two offices situated in a 1...
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Avail Clinical Research
860 Peachwood Drive
DeLand, Florida 32720
(386) 740-0770
Site Overview Avail Clinical Research is a renowned and experienced clinical research site conducting Phase...
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Suncoast Research Group, LLC
2128 W Flagler St # 201
Miami, Florida 33144
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Miami, FL
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Northwest Heart Clinical Research
Arlington Heights, Illinois 60005
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Asheville Cardiology Associates
Asheville, North Carolina 28802
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University of Colorado Health Sciences Ctr.
Aurora, Colorado 80045
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Maryland Cardiovascular Specialists
Baltimore, Maryland 21229
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Overlea Personal Physicians
Baltimore, Maryland 21236
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Northwest Clinical Research Center
Bellevue, Washington 98007
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Bellevue, WA
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Grace Research, LLC
Bossier City, Louisiana 71111
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Zasa Clinical Research
Boynton Beach, Florida 33437
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Advanced Clinical Research
Carmichael, California 95608
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Metrolina Internal Medicine
Charlotte, North Carolina 28204
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Charlotte, NC
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Cedar-Crosse Research Center
Chicago, Illinois 60607
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Chicago, IL
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Cardiac Research
Colorado Springs, Colorado 80909
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Aventiv Research
Columbus, Ohio 43213
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Georgia Heart Specialists
Covington, Georgia 30014
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Covington, GA
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Midwest CRC
Crystal Lake, Illinois 60012
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Partners in Clinical Research, LLC
Cumberland, Rhode Island 02864
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Cumberland, RI
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Cardiology Research Assoc.
Daytona Beach, Florida 32117
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Tooraj Joseph Raoof M.D., Inc.
Encino, California 91436
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Encino, CA
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Lillestol Research LLC
Fargo, North Dakota 58103
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Alan Graff, MD, PA
Fort Lauderdale, Florida 33308
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United Osteoporosis Center
Gainesville, Georgia 30501
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Gainesville, GA
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High Point Clinical Trials Center
High Point, North Carolina 27265
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High Point, NC
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East West Medical Institute
Honolulu, Hawaii 96814
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Honolulu, HI
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Heart Center Research, Llc
Huntsville, Alabama 35801
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Hutchinson Clinic
Hutchinson, Kansas 67502
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Hutchinson, KS
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Cape Cod Research Institute
Hyannis, Massachusetts 02601
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Hyannis, MA
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Indiana Heart Physicians
Indianapolis, Indiana 46237
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Indianapolis, IN
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Midwest Institute for Clinical Research
Indianapolis, Indiana 46260
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Nature Coast Clinical Research
Inverness, Florida 34452
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Irvine Clinical Research Center
Irvine, California 92618
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Clinical Investigation Specialists
Kenosha, Wisconsin 53142
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Holston Medical Group Clinical Research
Kingsport, Tennessee 37660
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Palm Research Center
Las Vegas, Nevada 89102
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VA Long Beach Healthcare System
Long Beach, California 90822
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Long Beach, CA
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Community Medical Associates Inc
Louisville, Kentucky 40207
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Louisville, KY
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Solaris Clinical Research
Meridian, Idaho 83646
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Meridian, ID
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Desert Clinical Research
Mesa, Arizona 85201
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Mesa, AZ
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ActivMed Practices & Research
Methuen, Massachusetts 01844
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Methuen, MA
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PMG Research of Charleston, LLC
Mount Pleasant, South Carolina 29464
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Mount Pleasant, SC
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Medex Healthcare Research, Inc.
New York, New York 10004
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New York, NY
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South Oklahoma Heart Research
Oklahoma City, Oklahoma 73135
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Oklahoma City, OK
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Central Phoenix Medical Clinic
Phoenix, Arizona 85020
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Research and Cardiovascular Corp.
Ponce, 00717
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Progressive Medical Research
Port Orange, Florida 32127
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Portland Preventive Cardiology, LLC
Portland, Oregon 97225
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Portland, OR
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Rancho Cucamonga Clinical
Rancho Cucamonga, California 91730
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Black Hills Cardiovascular Research Group
Rapid City, South Dakota 57701
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Rapid City, SD
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National Clinical Research - Richmond, Inc.
Richmond, Virginia 23294
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Richmond, VA
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Boice-Willis Clinic
Rocky Mount, North Carolina 27804
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Medex Healthcare Research, Inc.
Saint Louis, Missouri 63117
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Saint Louis, MO
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Saratoga Clinical Research LLC
Saratoga Springs, New York 12866
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Heart and Vascular Center of New Brunswick LLC
Somerset, New Jersey 08873
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Somerset, NJ
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Kootenai Heart Clinics
Spokane, Washington 99204
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Spokane, WA
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Encompass Clinical Research
Spring Valley, California 91978
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Northwest Houston Heart Center
Tomball, Texas 77375
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Tomball, TX
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University Clinical Investigators
Tustin, California 92780
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Diablo Clinical Research Inc
Walnut creek, California 94598
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Cardiology Partners Clinical Research Institute
Wellington, Florida 33449
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Wellington, FL
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Buffalo Cardiology & Pulmonary Associates
Williamsville, New York 14221
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