A Study of CFI-400945 Fumarate in Patients With Advanced Cancer

All participants will receive CFI-400945. At the beginning of the study, participants are
given a low dose of CFI-400945 and are watched very closely to see what side effects they
have and to make sure the side effects are not severe. If the side effects are not severe,
then more participants are asked to join the study and are given a higher dose of study drug.
Participants joining the study later on will get higher doses of study drug than participants
who join earlier. This will continue until the highest dose of study drug that can be taken
without severe side effects is found (called maximum tolerated dose). Doses higher than that
will not be given.

After the best dose of study drug is found, additional participants will be asked to join the
study and will be given the study drug at the maximum tolerated dose to further test the
safety and the drug at that dose.

Inclusion Criteria:

- Have histologic or cytological proof of advanced cancer that has progressed and for
which there is no further standard anticancer therapy available in the opinion of the
investigator.

- Patients must have measurable disease as per RECIST v1.1

- Are 18 years of age or older.

- Have clinically acceptable laboratory screening results within certain limits

- Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

- Able to swallow oral medications.

- Have a life expectancy greater than 3 months.

- Women and men of child producing potential must agree to use highly effective means of
contraception during study participation, and for at least 30 days after the last
administration of study medication.

- Negative serum pregnancy test with 72 hours prior to start of study drug

- Have the ability to understand the requirements of the study, provide written informed
consent which includes authorization for release of protected health information,
abide by the study restrictions, and agree to return for the required assessments.

- For expansion cohort, patients must consent to provide tissue from newly obtained
(during screening period) core or excisional biopsy of a tumor lesion.

Exclusion Criteria:

- Women who are pregnant or nursing.

- Have received radiotherapy, chemotherapy, biological therapy or investigational
treatment less than four weeks (six weeks for nitrosourea or mitomycin C) prior to
first dose of study medication or have not recovered from all acute toxicities from
prior treatments.

- Patients who have received growth factors within 14 days prior to initiation of dosing
of CFI-400945 fumarate.

- Have active, acute, or chronic clinically significant infections.

- Have uncontrolled severe hypertension

- Have clinical symptomatic congestive heart failure defined at >= Class II of the New
York Heart Association functional classification system or LVEF < 50% at baseline.

- Have active angina pectoris or recent myocardial infarction (within 6 months).

- Have chronic atrial fibrillation or QTc of greater than 470 msec, as calculated by
Bazett's correction formula.

- Have had major surgery within 21 days of starting therapy. Placement of a venous
access device within 21 days of starting therapy is allowed.

- Have additional uncontrolled serious medical or psychiatric illness.

- Have any medical condition that could impair the administration of oral agents
including significant bowel resection, inflammatory bowel disease or uncontrolled
nausea or vomiting.

- Known central nervous system metastasis. Patients with history of central nervous
system metastases are eligible if they are clinically or radiographically stable for
at least 3 months and not taking steroids or anticonvulsants.

- Patients being treated with full dose warfarin are excluded. Patients with history of
deep vein thrombosis or pulmonary embolus who are being treated with therapeutic doses
of low molecular weight heparin or prophylactic dose anticoagulants may be enrolled.

- Patients being treated with certain drugs not acceptable while receiving CFI-400945
fumarate.