Performance, Efficacy and Safety of Vibrating Capsule in Aiding Constipated Individuals



Status:Completed
Conditions:Constipation
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - 80
Updated:11/9/2017
Start Date:July 2014
End Date:February 2016

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Assessment of the Performance, Efficacy and Safety of Vibrating Capsule Medical Device in Aiding Reliving Constipated Individuals.

This is a study intended to evaluate the efficacy and safety of the vibrating capsule versus
sham non-vibrating capsule on spontaneous bowel movement, in aiding reliving Constipated
Individuals


Inclusion Criteria:

1. Patients aged 18 years and older.

2. Patients with chronic idiopathic constipation according to Rome III criteria and who
have not experienced relief of their symptoms from available therapies (osmotic and
stimulant laxatives which was used for at least one month at recommended dose).

3. Patients with more than 1 bowel movement/2 weeks and < 3 bowel movement/week.

4. Colonoscopy performed in the past 10 years prior to study participation, unless the
patients are <50 years old and without alarming signs and symptoms

5. Patient signed ICF

6. For women with childbearing potential, adequate contraception

Exclusion Criteria:

1. History of complicated/obstructive diverticular disease

2. History of intestinal or colonic obstruction.

3. History of significant GI disorder.

4. Use of following medication: Medication that may affect the bowel mobility,
Prokinetics, Anti-Depressants, medications for treatment of Parkinson disease,
Opiates, Calcium-channel Blockers, Aluminium/Magnesium Hydroxids

5. Clinical evidence of significant respiratory, CVS, renal, hepatic, biliary, endocrine,
psychiatric, neurologic, or presence of abdominal pacemakers.

6. Presence of pacemaker.

7. History of, or current eating disorders, such as anorexia, bulimia, or compulsory
overeating.

8. Diagnosis of mega-rectum or colon, a history of intestinal obstruction, congenital
anorectal malformation, clinically significant rectocele, or any evidence of
intestinal structural abnormality, including GI resection that affects bowel transit,
or any evidence of intestinal carcinoma or inflammatory bowel disease of alarm
symptoms such as weight loss, rectal bleeding, or anaemia.

9. History of Zenker's diverticulum, dysphagia or a known esophageal stricture 10.
Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs)

11. Participation in another clinical study in the last 4 months prior to screening.

12. Any other condition which in the opinion of the investigator may adversely affect the
safety of the patient or would limit the patient's ability to complete the clinical study.

13. Women who are pregnant or lactating.
We found this trial at
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Philadelphia, Pennsylvania 19140
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4800 Belfort Rd # 2
Jacksonville, Florida 32256
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Albuquerque, New Mexico 87109
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Ann Arbor, Michigan 48109
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1120 15th Street
Augusta, Georgia 30912
(706) 721-0211
Georgia Regents University Georgia Regents University, home of the Medical College of Georgia, is one...
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Bat Yam,
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Boston, Massachusetts 02114
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Chevy Chase, MD
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Houston, Texas 77030
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New York, New York 10016
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Pittsburgh, Pennsylvania 15206
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200 First Street SW
Rochester, Minnesota 55905
507-284-2511
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
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