Efficacy of High Flow Therapy in COPD At Home



Status:Terminated
Conditions:Chronic Obstructive Pulmonary Disease
Therapuetic Areas:Pulmonary / Respiratory Diseases
Healthy:No
Age Range:18 - 100
Updated:8/9/2017
Start Date:August 15, 2013
End Date:December 13, 2015

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Trial Summary
Trial Overview
Inclusion Criteria
Preliminary data show that in COPD patients, HFT substantially decreases ventilatory demand
during sleep. The central hypothesis of this proposal is that lowering ventilatory demand
using nasal high-flow therapy during sleep will elevate lung function, reduce dyspnea on
exertion and improve quality of life. Thus, this proposal aims will determine the effects HFT
over time on 1) lung function; 2) dyspnea on exertion; and 3) quality of life.


Inclusion Criteria:

- 1. Consenting adults over the age of 18 with COPD

Exclusion Criteria:

- 1. Apnea Hypopnea Index>15 events/hr 2. Use of Non-invasive positive pressure
ventilation (CPAP + Bilevel) 3. Severe bilateral nasal obstruction (apparent mouth
breathing at rest) 4. Documented clinical cardiovascular disease, as defined below:

1. myocardial infarction in past 3 months

2. revascularization procedure in past 3 months

3. implanted cardiac pacemaker or ICD

4. unstable arrhythmias

5. congestive heart failure with ejection fraction < 40%

6. uncontrolled hypertension (BP > 190/110) 5. History of end stage renal disease
(on dialysis) 6. History of end stage liver disease, such as:

1. Jaundice

2. ascites

3. history of recurrent gastrointestinal bleeding

4. transjugular intrahepatic portosystemic shunt (TIPS) ; 7. Transportation industry
worker (commercial truck or bus drivers, airline pilots) 8. Known pregnancy (by
self report) 9. Known coagulopathy or anticoagulant use (e.g. coumadin) other
than aspirin. 10. Do you take medications for any of the following reasons:

1. Pain control (besides NSAIDs)

2. Sleep medication

3. Benzodiazepines

4. Methadone
We found this trial at
1
site
Johns Hopkins University
3400 N Charles St
Baltimore, Maryland 21205
410-516-8000
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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mi
from
Baltimore, MD
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