Magnetic Resonance Elastography in Hydrocephalus
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 45 - 95 |
| Updated: | 5/25/2018 |
| Start Date: | March 1, 2007 |
| End Date: | December 30, 2019 |
The purpose of this project is to assess the utility of a new magnetic resonance technique
called magnetic resonance elastography (MRE) in the non-invasive diagnosis of normal pressure
hydrocephalus. The investigators hypothesize that MRE produces a unique imaging signature for
hydrocephalus that distinguishes the disease from the normal (non-hydrocephalic) but
atrophied brain, a distinction not possible with conventional MR imaging studies that are
presently available.
called magnetic resonance elastography (MRE) in the non-invasive diagnosis of normal pressure
hydrocephalus. The investigators hypothesize that MRE produces a unique imaging signature for
hydrocephalus that distinguishes the disease from the normal (non-hydrocephalic) but
atrophied brain, a distinction not possible with conventional MR imaging studies that are
presently available.
Inclusion Criteria:
- Age >21;
- One or more of the following complaints: memory loss/dementia, urinary incontinence,
or progressive gait disturbance
- Ventriculomegaly defined as temporal horn width >2 mm or a FH:ID ratio>30% on computed
tomography or MRI, where FH is the maximal distance between the frontal horns and ID
is the internal diameter from inner table to inner table of the skull at this level
(Greenberg)
- A diagnosis of any adult onset hydrocephalus (NPH, post-traumatic, post-hemorrhagic,
obstructive, or idiopathic) will be considered for enrollment in this study
Exclusion Criteria:
- Implanted neuro-stimulator or cardiac pacemaker
- Known coagulopathy; major organ dysfunction
- End-stage congestive heart failure
- Oxygen-dependent pulmonary disease, hepatic cirrhosis, or dialysis- dependent renal
failure; or other condition which, according to the assessment of the treating surgeon
or anesthesia team
- Precludes consideration of elective surgery
- Patients who may be pregnant will be excluded from this study as well
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