BOTOX® Efficacy and Safety in the Treatment of Knee Osteoarthritis



Status:Active, not recruiting
Conditions:Arthritis, Osteoarthritis (OA)
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:40 - 75
Updated:4/21/2016
Start Date:October 2014
End Date:April 2016

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Trial Summary
Trial Overview
Inclusion Criteria

This study will evaluate the efficacy and safety of a single intra-articular injection of 2
doses of BOTOX® (onabotulinumtoxinA) compared with placebo as treatment for knee
osteoarthritis symptoms.


Inclusion Criteria:

- Painful osteoarthritis

- Able to discontinue anti-inflammatory drugs and analgesics

- Must be ambulatory without assistive walking devices

Exclusion Criteria:

- Chronic pain conditions other than knee osteoarthritis

- Treatment with corticosteroids in the study knee within 12 weeks

- Treatment with hyaluronic acid in the study knee within 24 weeks

- Previous treatment with any botulinum toxin for any reason

- Diagnosis of myasthenia gravis, Eaton-Lambert syndrome, or amyotrophic lateral
sclerosis
We found this trial at
2
sites
Clinical Trial Facility in Pardubice
Pardubice,
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Pardubice,
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Clinical Trial Facility in Artesia California
Artesia, California 90701
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Artesia, CA
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