BOTOX® Efficacy and Safety in the Treatment of Knee Osteoarthritis
Status: | Active, not recruiting |
---|---|
Conditions: | Arthritis, Osteoarthritis (OA) |
Therapuetic Areas: | Rheumatology |
Healthy: | No |
Age Range: | 40 - 75 |
Updated: | 4/21/2016 |
Start Date: | October 2014 |
End Date: | April 2016 |
This study will evaluate the efficacy and safety of a single intra-articular injection of 2
doses of BOTOX® (onabotulinumtoxinA) compared with placebo as treatment for knee
osteoarthritis symptoms.
doses of BOTOX® (onabotulinumtoxinA) compared with placebo as treatment for knee
osteoarthritis symptoms.
Inclusion Criteria:
- Painful osteoarthritis
- Able to discontinue anti-inflammatory drugs and analgesics
- Must be ambulatory without assistive walking devices
Exclusion Criteria:
- Chronic pain conditions other than knee osteoarthritis
- Treatment with corticosteroids in the study knee within 12 weeks
- Treatment with hyaluronic acid in the study knee within 24 weeks
- Previous treatment with any botulinum toxin for any reason
- Diagnosis of myasthenia gravis, Eaton-Lambert syndrome, or amyotrophic lateral
sclerosis
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