Effect of HBO on Functional Connectivity of Resting State Networks in Patients With Cerebral Small Vessel Disease
| Status: | Terminated |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 50 - 90 |
| Updated: | 11/1/2017 |
| Start Date: | September 16, 2014 |
| End Date: | October 4, 2017 |
The Effect of Hyperbaric Oxygen on the Functional Connectivity of Resting State Neural Networks in Patients With Cerebral Small Vessel Disease
The purpose of this study is to extend our previous work, in which we demonstrated an
increase in the internal and cross network connectivity of resting state neural networks in
patients with cerebral small vessel disease by treatment with hyperbaric oxygen, to at least
20 more individuals.
increase in the internal and cross network connectivity of resting state neural networks in
patients with cerebral small vessel disease by treatment with hyperbaric oxygen, to at least
20 more individuals.
Patients without contraindications to Hyperbaric Oxygen treatment or magnetic resonance
imaging who exhibit white matter hyper-intensities on MRI will be recruited to have a
functional MRI followed by10 hyperbaric oxygen treatments at 2 ATA for one hour. These
treatments will be done once daily, from Monday through Friday, on 2 consecutive weeks. 4-6
weeks later, they have a repeat fMRI. These fMRI's will be analyzed regarding any changes in
the resting state connectivity of various circuits.
imaging who exhibit white matter hyper-intensities on MRI will be recruited to have a
functional MRI followed by10 hyperbaric oxygen treatments at 2 ATA for one hour. These
treatments will be done once daily, from Monday through Friday, on 2 consecutive weeks. 4-6
weeks later, they have a repeat fMRI. These fMRI's will be analyzed regarding any changes in
the resting state connectivity of various circuits.
Inclusion Criteria: Over 50 years of age White Matter Hyperintensities on MRI @ or more
symptoms and/or neurological impairments e.g. gait disturbances,disequilibrium, decline in
cognitive function, upper motor neuron deficit, dysmetria, hyper-refexia or unilateral
increase in motor tone -
Exclusion Criteria: Contraindications to hyperbaric oxygen therapy e.g. pulmonary emphysema
or bullae, claustrophobiia, seizure diorder Inability of the patient to tolerate
pressurization e.g. Eustachian tube dysfunction Stroke within the previous 6 months Extreme
cognitive impairment Major depression Other uncontrolled co-morbidities, e.g. diabetes,
hypertension, thyroid disorders, carotid artery stenosis (>70%), renal or hepatic
dysfunction History of brain tumor, head trauma, electric shock therapy, brain irradiation
History of migraine headaches
We found this trial at
3
sites
Saint Louis, Missouri 63110
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