Phendimetrazine and Cocaine
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 9/29/2017 |
| Start Date: | September 2014 |
| End Date: | December 2015 |
Safety and Tolerability of Cocaine During Phendimetrazine Maintenance
This study will determine the safety and tolerability of phendimetrazine (Bontril®) as a
pharmacotherapy for cocaine use disorder. A rigorous, inpatient human laboratory study will
be conducted in which the subjective and physiological effects of cocaine are evaluated
during maintenance on placebo and phendimetrazine.
pharmacotherapy for cocaine use disorder. A rigorous, inpatient human laboratory study will
be conducted in which the subjective and physiological effects of cocaine are evaluated
during maintenance on placebo and phendimetrazine.
Inclusion Criteria:
- Recent cocaine use
Exclusion Criteria:
- Abnormal screening outcome (e.g., ECG, blood chemistry result) that study physicians
deem clinically significant
- Current or past histories of substance abuse or dependence that are deemed by the
study physicians to interfere with study completion
- History of serious physical disease, current physical disease, impaired cardiovascular
functioning, chronic obstructive pulmonary disease, history of seizure or current or
past histories of serious psychiatric disorder that in the opinion of the study
physician would interfere with study participation will be excluded from participation
- Females not currently using effective birth control
- Contraindications to cocaine or phendimetrazine
We found this trial at
1
site
Lexington, Kentucky 40507
Principal Investigator: William W Stoops, Ph.D.
Phone: 859-257-5388
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